Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/...
bilayer membrane, whereas below the temperature, phospholipids exist in a gel state and are not able to form liposomes. In addition, the effect of formulation on liposome stability, storage temperature, and drug release is also related to the phase transition temperature; drug release from...
J. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 26, 363–372 (2019). CAS Google Scholar Lou, G. et al. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid ...
acheapness 粗劣 [translate] aabsorb all launched inventory in market 吸收所有被发射的存货在市场上 [translate] aA new lipid-based nanoparticle formulation has been developed as carrier for docetaxel. 一种新的基于油脂的nanoparticle公式化被开发了作为载体为docetaxel。 [translate] ...
Characterization of saRNA lipid nanoparticle formulations.aSchematic of saRNA formulated on the interior or exterior of the lipid nanoparticles, with ionizable (C12-200) or cationic (DDA, DOTAP) complexing lipids.bParticle diameter (in nm) as determined by Nanoparticle tracking analysis (NTA) (bar ...
Lipid nanoparticle formulation optimization for in vivo mrna Delivery with design of experiment methodologies Introduction: Although messenger RNA (mRNA) has great potential to treat various diseases, its successful intracellular delivery remains challenging[1]. Lipid nanoparticles (LNPs) have been widely us...
The aim of the present study was to develop, characterize and optimize a solid lipid nanoparticle system to deliver budesonide to the lungs. Budesonide-loaded solid lipid nanoparticles were prepared by the emulsification-solvent diffusion method. The impact of various processing variables including ...
Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA Although mRNA and siRNA have significant therapeut Ball,Rebecca,L.,... - 《Nano Letters》 被引量: 2发表: 2018年 Data-driven development of an oral lipid-based nanoparticle formulation of a hydrophobic drug Due to its ...
nanoparticle level. By differentiating unencapsulated mRNAs, empty LNPs and mRNA-loaded LNPs via coincidence analysis of fluorescent tags on different LNP components, and quantitatively resolving single-mRNA fluorescence, we reveal that a commonly referenced benchmark formulation using DLin-MC3 as the ...
Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model Article 04 December 2024 The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo Article Open access 11 April 2024 Data...