Though ROS and their reaction products may act as second messengers in regulating complex downstream effects on primary and secondary metabolism, reaction of unmetabolized ROS with lipids can cause irreversible damage to their structure, initiate oxidation and subsequently halt plant cellular metabolism. ...
Reprogrammed fatty acid metabolism mainly characterized by increased de novo lipgenesis has been increasingly established as a hallmark of cancer. Elevated lipgenesis, including de novo fatty acid synthesis1,2and cholesterol biosynthesis3,4, provides cancer cells with building blocks, signaling molecules ...
In subject area: Medicine and Dentistry Lipid metabolism refers to the process of digestion, absorption, synthesis, and decomposition of fats in living organisms by various enzymes. From: Biomedicine & Pharmacotherapy, 2023 About this pageSet alert ...
Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic alterations are most highly correlated with age prediction, contributes to aging by regulating lipid metabolism. We applied artificial intelligence to predict the protein structure of ELOVL2 and the interaction with its ...
Besides, modulating lipid metabolism in stromal cells and immune cells also provides a new choice for anti-tumor therapy. Moreover, it can be combined with chemotherapy and immunotherapy, providing a new comprehensive strategy for optimizing cancer treatment. This review aims to clarify the lipid ...
Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep–wake cycles Article Open access 23 January 2024 Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation Article Open access 24 May 2023 Main...
Type 2 diabetes mellitus (T2DM) is an endocrine metabolic disorder characterized by dysfunctional pancreatic β-cells and peripheral insulin resistance, resulting in abnormalities of glucose metabolism, dyslipidemia, and chronic inflammation [1]. T2DM is commonly associated with poor blood glucose control,...
The metabolism of cells in inflammatory and noninflammatory arthritic joint diseases is subject to complex environmental controls. The aim of the present s... S Sarban,A Kocyigit,M Yazar,... - 《Clinical Biochemistry》 被引量: 316发表: 2005年 Changes in Antioxidant Enzyme Activities and Lipid...
Our results enrich the knowledge on stress-induced PUFA biosynthesis and the putative role of ROS in the regulation of lipid metabolism in oleaginous thraustochytrids. This study provides a new and alternate strategy for cost-effective industrial fermentation of PUFA. 展开 ...
Metabolomics and lipidomics approaches have provided insightful evidence of altered metabolic pathways in NAFLD and NASH. There is an association between circulating amino acids and steatohepatitis, and impairment in amino acid metabolism in NAFLD is strongly correlated with insulin resistance, particularly ...