Bile salt, cholesterol and phospholipid are co-secreted in bile in the form of mixed micellar complexes in a molar ratio of approximately 16:4:1. Critical micelle concentration The minimum concentration of a surfactant in a bulk solution that leads to spontaneous formation of surfactant micelles. ...
K., Effect of various lipid-bile salt mixed micelles on transfer of amphotericin-B across the everted rat intestine. Drug Dev. Ind. Pharm. , 21, 2021–2027 (1995).Dangi JS, Vyas SP, Dixit VK (1998) Effect of various lipid-bile salt mixed micelles on the intestinal absorption of Am-...
Describe the role of bile salt in lipid digestion. Bile: Bile is a digestive substance secreted by the liver and temporarily stored in the gallbladder before it is released into the small intestine. Bile is mainly composed of water with dissolved substances such as bile salts, cholesterol, and...
bile salts for its activity. It has multipleisoformsand apparently requires a 2 : 1 bile salt-to-phosphatidylcholine molar ratio for optimal activity. Although the bulk of intestinal PLA2activity is derived frompancreatic juice, there is some contribution from the intestinal mucosa, where the ...
A strategy that has attracted special attention in recent years, especially for the delivery of peptides, is hydrophobic ion pairing [85]. Charged hydrophilic molecules are paired with counter ions, leading to lipophilic complexes that can be dissolved in the oily phase of lipid-based drug deliver...
C. et al. Detergent-free formation and physicochemical characterization of nanosized lipid–polymer complexes : Lipodisq. Angew. Chemie Int. Ed. 51, 4653–4657 (2012). 6. Jamshad, M. et al. Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction...
Intragastric lipolysis may be particularly important for the digestion of milk lipid since milk fat globules are resistant to pancreatic lipase without prior disruption; milk bile salt stimulated lipase (BSSL) may supplement further intestinal hydrolysis. Previous information on gastric lipolysis has been...
et al. SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res. 46, W296–W303 (2018). Article CAS PubMed PubMed Central Google Scholar Chovancova, E. et al. CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures. PLoS ...
The theory behind this states that the polar solvent can break the bonds between the polar lipid-non-polar lipid complexes and the non-polar solvent will solubilize the non-polar lipids which are desired for the production of biodiesel [218]. The drawback of polar solvent is that it extracts...
Lactobacillus and Bifidobacterium have been shown to increase the excretion of bile acids from the gastrointestinal tract via bile salt hydrolase enzymatic activity. This makes bile acids less water-soluble and thus more easily excreted by removing the amino acid moiety through deconjugation [119]. ...