Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial role in the digestion and absorption of nutrients. The importance of BS for controlled release and transport of lipid soluble nutrients and drugs has recently stimulated scientific interest in these...
Describe the role of bile salt in lipid digestion. Bile: Bile is a digestive substance secreted by the liver and temporarily stored in the gallbladder before it is released into the small intestine. Bile is mainly composed of water with dissolved substances such as bile salts, cholesterol, and...
Bile acids (BA), which for decades were considered to only be involved in lipid digestion in the intestinal lumen and cholesterol solubilization in the bile, now seem to have pleiotropic effects: contributing to the homeostasis of lipids, glucose and other metabolic substrates (Li & Chiang 2014,...
The ingestion of food initiates a series of physiological changes in the gastrointestinal (GI) tract. Table 1 summarizes these changes as the ingested food moves from the esophagus to the stomach, initiating dynamic changes in digestion that can impact drug formulations. The stomach’...
In the duodenum, the two most important factors in the digestive process, are the intraluminal levels of pancreatic lipase (for fat hydrolysis) and of bile salts (for the solubilization of the lipids before and during lipolysis). FAT DIGESTION IN THE NEWBORN Whereas the absorption of dietary ...
C. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities. J. Lipid Res. 23, 70–80 (1982). CAS PubMed Google Scholar Heuman, D. M. Quantitative estimation of ...
This research revealed that the delayed digestion of fats and oils in the small intestine were brought on by the addition of dietary fiber to the MA. The degree of protein hydrolysis in the actual beef was a little higher than that of PB beef analog (54.0 %), but a little lower (15.8...
Central aspects of the cellular lipid trafficking mechanisms that occur during keratinocyte differentiation are still not well understood. In the past years, evidence has accumulated to suggest that members of the superfamily of adenosine triphosphate binding cassette (ABC) transporters are critically ...
Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors. Disrupted BA transport and homeostasis results in the development of cholestat
bile acids that are prone to enterohepatic circulation between the gallbladder and the liver. Cholesterol absorption in the intestine and cholesterol secretion into the bile both require bile salts, which are, together with enterohepatic circulation of BAs, crucial for balancing the plasma cholesterol ...