1 Human ABCB11, also known as bile salts export pump (BSEP), is the major exporter for the specific secretion of bile salts. Correspondingly, defects of ABCB11 function, due to either mutations or side effects of medicines, lead to inherited or acquired diseases, respectively, such as ...
Bile Salts: Structure, Distribution, and Possible Biological Significance as a Species CharacterIn the last few years, the increasing interest in location-based services (LBS) has favored the introduction of geo-referenced information in various Web 2.0 applications, as well as the rise of location...
The structures of particles found in isotropic phases of mixed surfactant systems consisting of conjugated bile salts and fatty lipids were assessed using small-angle neutron scattering. The conjugated bile salts were either cholylglycine or chenodeoxycholylglycine. The fatty lipids were mixtures of ...
I. AcrAB and related multidrug efflux pumps of Escherichia coli. J. Mol. Microb. Biotechnol. 3, 215–218 (2001) CAS Google Scholar Thanassi, D. G., Cheng, L. W. & Nikaido, H. Active efflux of bile salts by Escherichia coli. J. Bacteriol. 179, 2512–2518 (1997) Article CAS ...
AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC. We have determined the crystal structure of AcrB at 3.5 Å resolution. Three AcrB protomers are organize
Alkaline phosphatase, enzyme that is normally present in high concentrations in growing bone and in bile. It is essential for the deposition of minerals in the bones and teeth. Alkaline phosphatase deficiency is a hereditary trait called hypophosphatasia
bile salts must be present or stones will develop! Sphincter of Oddi is stimulated by a secretion that relaxes the sphincter allowing bile releaseStructure of Pancreasprovides digestion of fat through emulsification- - - large , many lobedposterior to stomachthe aorta, inferior vena cava and hepatic...
7β-Hydroxysteroid dehydrogenases (7β-HSDHs; EC 1.1.1.201), including that from the intestinal microbe Collinsella aerofaciens , catalyse the NADPH-dependent reversible oxidation of secondary bile-acid products to avoid potential toxicity. Here, the first structure of NADP + bound to dimeric 7β...
Toxic compounds have always been part of the natural environment in which microorganisms dwell. The development of strategies for life in this habitat has been crucial for survival of the cell. As a result, microorganisms have developed versatile mechani
A gel filtration chromatographic study of CHAPS, a nondenaturing zwitterionic surfactant, reveals a step-wise self-association of CHAPS, which provides important information about its use for membrane biochemistry and about micelle formation of bile salts.doi:10.1002/chin.198338367...