atherosclerosis, and other obesity-related diseases[29,30]. In recent years, increasing evidence proposes a link between steroid imbalance and IDD.Estrogen deficiencyinpostmenopausal womenis positively associated with IDD development, and estrogen is involved in regulating IVD c...
Lipid metabolisminvolves the creation, trafficking, and degradation oflipids. Perhaps the paradigm interaction oflipid metabolismwith other biological systems would be during the pathological process ofatherosclerosis. Oxidized lipids taken up by dysfunctional endothelial cells stimulate inflammatory cells and cy...
The major focus of ALPAC was on the role of nutrition, in particular of antioxidative micro-nutrients, in the etiology of cardiovascular disease and cancer discussed by some of the world's leading scientists. Concurrently, the International Conference on Quality and Safety Aspects of Food and ...
LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2007;192(1):211-217. doi:10.1016/j.atherosclerosis.2006.05.007 PubMedGoogle ScholarCrossref 52. Ridker PM, Everett BM, Thuren T, ...
Acquisition of a lipid-laden phenotype by immune cells has been defined in infectious diseases and atherosclerosis but remains largely uncharacterized in cancer. Here, in breast cancer models, we found that neutrophils are induced to accumulate neutral lipids upon interaction with resident mesenchymal cel...
The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in
mice, deletion of ACAT1 results in both impairment of ABCA1 dependent cholesterol efflux and elevated atherosclerosis [154]. Moreover, among the PAT protein family of LDs, adipose differentiation-related protein (ADFP) was strongly associated with foam cell formation and atherosclerosis [155,156]....
Coming drug is Pharmcogenetics for atherosclerosis 12:00 pm GE Ballroom Lunch 12:15 pm – 12:30 pm GE Ballroom Austen-Braunwald Award Awarded to one BWH and one MGH First Look participant who embodies the innovative, entrepreneurial, and visionary spirit of cardiovascular legends W. Gerald Au...
Cholesterol is essential to form cell membranes,bile acidsand steroid hormones. On the other hand, oxidized cholesterol metabolites are cytotoxic and represent risk factors foratherosclerosis[109]. Therefore, cholesteroldetoxificationis crucial to protect the body from excess cholesterol. The mitochondrial ...
[20] was developed to perform the lipidomics analysis and identified more than 17 lipid classes successfully, which has been applied for comprehensive lipid profiling of serotonin deficiency mice serum and human plasma from atherosclerosis patients or breast cancer patients [21], [22], [23]. In ...