Linkage disequilibrium (LD), which refers to nonrandom association of alleles(等位基因的非随机性组合） at different loci(位点；基因座)。 LD指等位基因在不同位点（或基因座）的的非随机性组合。Block:阻滞 linkage diseqquilibrium block：等位基因在不同基因座的非随机性组合障碍 因为对这方面不...
Linkage disequilibriumSimmentalPolish RedDifferences in level of LD were found between commercial and native breeds.Shorter haplotype block structure in Polish Red than in both commercial breeds.Population history and breeding schemes may influence patterns of LD....
The development of linkage disequilibrium (LD) maps and the characterization of haplotype block structure at the population level are useful parameters for guiding genome wide association (GWA) studies, and for understanding the nature of non-linear association between phenotypes and genes. The elucidati...
Haplotype block structure is conserved across mammals PLoS Genet, 2 (2006), pp. 1111-1118, 10.1371/journal.pgen.0020121 View in ScopusGoogle Scholar Hill, 1974 W.G. Hill Estimation of Linkage Disequilibrium in Randomly Mating Populations Heredity (Edinb), 33 (1974), pp. 229-239 CrossrefView...
This method incorporates dense linkage disequilibrium block structure of SNPs for prioritizing a set of genetic variants using GWAS summary statisticis before performing fine-mapping. - GitHub - cmomo/LocNet: This method incorporates dense linkage diseq
We consider six different strategies to decompose or represent the empirical LD using this “Banded + LR" structure (Table 2), all of which take the form of the expression in Eq. (4), but differ in terms of (1) whether the banded component is a diagonal matrix, in which case the ...
Gaut, B.S., Long, A.D., 2003 The lowdown on linkage disequilibrium. Plant Cell 15(7): 1502-1506. ArticlePubMedCASGoogle Scholar Hagenblad, J., Nordborg, M., 2002, Sequence variation and haplotye structure surrounding the flowering time locusFRIinArabidopsis thaliana. Genetics 161: 289-29...
J Hum Genet (2008) 53:850–856 DOI 10.1007/s10038-008-0309-8 SHORT COMMUNICATION Linkage disequilibrium structure of the 5q31-33 region in a Thai population Pornlada Nuchnoi Æ Jun Ohashi Æ Izumi Naka Æ Duangporn Nacapunchai Æ Katsushi Tokunaga Æ Nao Nishida Æ Jintana Patar...
Multipoint Linkage-Disequilibrium Mapping with Haplotype-Block Structure The HapMap Project is providing a great deal of new information on high-resolution haplotype structure in various human populations. This information has t... M Zheng,MS Mcpeek - 《American Journal of Human Genetics》 被引量:...
Demography, Recombination Hotspot Intensity, and the Block Structure of Linkage Disequilibrium Background: Effective gene mapping based on genetic association data will require detailed knowledge of patterns of linkage disequilibrium (LD) in human po... Michael,P.H.,Stumpf,... - 《Current Biology》...