KEy TLR LIGANDS AND THEIR RECEPTORSLigands, T L R
Active sites of ligands and their receptors are made of common peptides that are also found elsewhere 来自 国家科技图书文献中心 喜欢 0 阅读量: 13 作者: S Ohno 展开 摘要: The simultaneous emergence in evolution of a ligand and its receptor might have entailed their active sites being ...
A potential solution to the conundrum of polypeptide hormone specificity has recently emerged in a series of articles detailing the intranuclear translocation and action of peptide ligands and their receptors, or fragments thereof. As contrasted later, striking parallels in the intranuclear actions of pep...
bovine, and human lung [24–28]. A recombinant soluble isoform takes on a dominant-negative phenotype and blocks signaling. Soluble RAGE can act as an extracellular "decoy receptor", antagonizing fl-RAGE and other receptors by binding DAMPs and other ligands...
EPH receptors (EPHs), together with cell-bound signalling-competent ligands (ephrins), regulate cell positioning, tissue patterning and stem cell maintenance during normal and neoplastic development. Their specialized functions are driven via the signalling of oligomeric EPH–ephrin clusters into both int...
The high symmetry and stability of phenalenyl systems, both as the planar π-radical (P·) and as the π-cation (P~+), are desirable characteristics of prototypical aromatic donor/acceptor pairs that encourage their use as (binary) model... D Small,V Zaitsev,Y Jung,... - 《Journal of...
Next, for the second series of molecular docking conducted, the PDB files of the enzymes and their individual putative ligands, were considered as the receptors and ligands, respectively. For the last series of molecular docking, each of the PDB files of the enzyme-ligand complexes constructed ...
ERα and other nuclear receptors such as the glucocorticoid receptor (GR) are easily extracted from the nucleus in the presence of low concentrations of detergents such as NP40 (V. Marsaud and H. Richard-Foy, unpublished observations). As a consequence, apparent enrichment of ERα or GR in...
receptors complexed with their ligands has been proposed yet; so, a convincing hypothesis on the basis of recognition is currently unavailable, despite several anti-leukotriene agents are already available in the market and others have already successfully started their track in drug development trials....
The antipsychotic and anti-schizophrenic drugs that are currently in use have very strong side effects that are mainly due to their action on dopamine receptors. The side effects often involve irreversible damage to the extrapyramidal nervous system which controls movement functions of the brain. Patie...