A new method has been proposed for analysis of experimental data on ligand-receptor binding at equilibrium. This method makes it possible to detect heterogeneity of a receptor system in cases where the contribution of the high-affinity site to total binding is rather small and the problem of ...
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotro... A variety of humoral factors modulate the osteoclastogenesis. Receptor activator of NF-魏B ligand (RANKL) expressed on osteoblast/stromal lineage...
However, the difference of interaction mode between ligand/receptor and antibody/receptor was still unknown. In this study, the complexes of CD16/Fc fragment dimers and CD16/B88-9 were analyzed by using computer-aided method. The solvent accessible area and surface electrostatic Acknowledgements ...
There are two main receptor types for externally induced apoptosis. Death receptors (e.g., TNF, Fas receptors) bind their extracellular ligands (TNF-alpha, FasL – Fas ligand, respectively). This prompts their activation and assembly into complexes, leading to the activation of intracellular caspas...
Difference in the expression of Fas/Fas-ligand and lymphocyte subset re- constitution according to the occurrence of acute GVHD. Bone Marrow Trans- plant. 20:883. factor-B and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor- associated factor 2. Proc. Natl. Acad. Sci. ...
An important implication of the mentioned work is that the introduction of the second ligand may give rise to the conformational isomerization of metal NCs because the second ligand provides diverse inter(intra)-NP interactions and influences the symmetry of the ligand shell. Nevertheless, it is ...
Bombesin-receptor-subtype-3 (BRS-3) is an orphan G-protein-coupled receptor of the bombesin (Bn) family whose natural ligand is unknown and which does not ... Paola,Moreno,Samuel,... - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 4发表: 2013年 Bombesin Receptor Subtype-...
Further experiments revealed that having a glutamine in that position significantly increased the sensitivity of the MCR4 receptor to the ligand that naturally activates it. "Our data suggest that the melanocortin system is more highly regulated in whales that hunt—and, conversely, that the giant ...
Critical review of the methods used to measure the apparent dissociation constant and ligand purity in Ca2+ and Mg2+ buffer solutions John A.S. McGuigan, ... Hugh Y. Elder, in Progress in Biophysics and Molecular Biology, 2006 E measured potential difference (mV) E0 constant of the recordi...
The presence of mature CD83+DCs (0, ≥1) significantly differed among disease types (p = 0.001). A significant difference was found between the UC and control groups (p = 0.002) as well as between the UC and CD groups (p = 0.018). There was no difference between the co...