Gupta, S., Singh, L., Chellappa, M.M., Dey, S., 2015. Toll-like receptor ligands and their combinations as adjuvants-current research and its relevance in chickens. Worlds Poult. Sci. J. 71, 95-110.Gupta SK, Singh LV, Chellappa MM, Dey S. Toll-like receptor ligands and their ...
Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the three-dimensional structure that a protein will adopt based solely on its amino acid sequence—the structure prediction component of the ‘protein folding problem’ 8 —...
The interaction of the type-1 parathyroid hormone receptor (PTHR1), a class B1 GPCR, with its ligands has served as an exemplar of this two-site mechanism of ligand binding. PTHR1 is bound by two naturally occurring peptide hormones, parathyroid hormone (PTH) and PTH-related protein (PTHrP...
The type of linkage that is formed between the matrix and the immobilized ligand affects the performance of the affinity support in a number of ways. For example, if the linkage blocks or adversely affects the structure o...
(Fig.2b), suggesting that hits for these ligands, if present in the library, were exceedingly rare. As a reference, the wildtype TtgR’s F-scores for its native ligands phloretin (2.0) and naringenin (1.9) were considerably lower than those observed for the library at the 99th percentile...
Cell-based tests hold great potential to evaluate not only ligand binding but also its capacity to trigger bio- logical responses relevant for the physiological context. This holds true at least for cases in which the "reporter" cell type is physiologically relevant. It is noteworthy that ...
The NR4A receptors exhibit high constitutive activity,21 which is also reflected by the corresponding Gal4-hybrid receptors, and can thus be activated (agonists) or repressed (inverse agonists). Both types of ligands are relevant for the development of chemical tools and may hold therapeutic potent...
Annexin I (Anx A1) and its N-Terminal Peptides It is intriguing that some FPR agonists have dual roles in inflammatory responses. Anx A1, also named lipocortin I, is a glucocorticoid-regulated, phosphorylated-binding protein possessing both proinflammatory and anti-inflammatory activity mediated in...
and its relationship to prognosis in hepatocellular carcinoma Jia‑Jia Dong1, Li Ying1 and Ke‑Qing Shi2,3* Open Access Abstract Background: The Wnt gene family members are known to participate regulating various normal and pathologi‑ cal processes including ...
J. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell 4, 403–414 (1999). Article CAS PubMed Google Scholar Adams, R. H. et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development...