Bregestovski, PiotrMaleeva, GalinaGorostiza, PauJohn Wiley & Sons, Ltd (10.1111)British Journal of PharmacologyBregestovski P, Maleeva G, Gorostiza P (2018). Light-induced regulation of ligand-gated channel activity. Br J Pharmacol 175: 1892-1902....
Intracellular ligands can increase (Ca2+, cAMP, IP3) or decrease (cGMP, ATP) activity of the associated channel. These channels play important roles in cell function. For example, Ca2+-dependent potassium, chloride and non-specific cation channels modify the excitability of the nerve cell ...
Ligand-gated channels (LGCs) play a fundamental role in the fast transmission of electrical activity from neuron to neuron and/or to effector cells. Studie... D.,Bertrand,B.,... - 《Journal of Receptors & Signal Transduction》 被引量: 22发表: 1997年 Assay for the presence, in cultured...
These other proteins can also be modulated by these interactions with ion channel receptors. This bidirectional functional cross-talk is important for critical cellular functions such as excitotoxicity in pathological and disease states like stroke, and for the basic dynamics of activity-dependent ...
Free Essay: Ligand-gated ion channels, such as GABAA receptors, generate a current by moving ions through the pore of the channel across the membrane. Ion...
A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. An excitatory amino-acid transporter with properties of a ligand-gatedchloride channel New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. ...
Indeed, to treat most CNS disorders, drugs must limit pathological neuronal activity without disrupting the rich underlying functionality of the brain. The existing evidence for promiscuity raises the possibility that modulating multiple nodes of a network of interacting components may be more appropriate...
Ion channels are at the heart of many biologicla processes such as nerve activity and muscle contracction. How are their impressive ion selectivity and highly specialized gating brought about? In recent years, X-ray crystallography and high-resolution electron microscopy, as well as photo-affinity ...
Channel activity of recombinant pannexin 1 Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity... RA Romanov,MF Bystrova,OARS Kolesnikov - 《Biochemistry》 被引量: 6发表: 2011年 加载更多来源...
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present