The α7 neuronal nicotinic receptor (α7 nAChR) is a homopentameric ligand-gated ion channel expressed in mammalian central nervous system regions associated with cognitive processing. α7-selective agonists have demonstrated activity in rodent models of cognition. A hallmark of α7 receptor activation...
5. Individual wells are analyzed spectrophotometrically to quantitate formazan production, and in addition are viewed microscopically for detection of viable cells and confirmation of protective activity. 6. Drug-treated virus-infected cells are compared with drug-treated noninfected cells and with other...