These receptors respond to synaptically released neurotransmitters, circulating hormones and locally released substances. Cell surface receptors are also targets for many therapeutically used drugs. This review will focus on ligand-gated ion channels, i.e. receptors in which the ligand binding site and...
Figure 2.Diagram for ligand-gated ion channelsSiegelbaum et al (2000). View chapterExplore book Signalling mechanisms Mark LMayer, inCurrent Opinion in Neurobiology, 2005 arethat mediate information transfer at synapses. Their function relies on the ability to respond very rapidly to the transient ...
Ligand-gated ion channels in the enteric nervous system There are many cell surface receptors expressed by neurones in the enteric nervous system (ENS). These receptors respond to synaptically released neurotran... J.,J.,Galligan - 《Neurogastroenterology & Motility》 被引量: 136发表: 2002年 ...
All rights reserved. lig·and-·gat·ed chan·nel a class of ion channels the ionic permeability of which is regulated by cell membrane receptors that respond to specific extracellular chemical signals. Farlex Partner Medical Dictionary © Farlex 2012...
2, ELIC does not respond to protons by gating open its channel. In contrast, EG-I9′A does gate open in response to increasing proton concentrations (Fig. 3c). The magnitudes of the proton-gated currents are significantly higher than those observed in uninjected or mock-injected oocytes (...
These receptors respond to neurotransmitter binding with allosteric transitions that switch the protein from a non-conducting closed conformation to an ion-conducting open conformation rapidly and with high probability. Our understanding of the protein movements underlying these conformational transitions is ...
Medicine, New York, New York 10016 KEY WORDS patch clamp; whole-cell currents; neurotransmitters; calcium; phosphatase ABSTRACT To understand information processing in the retina, it is important to identify and characterize the types of synaptic receptors and intrinsic ion channels in retinal neurons...
The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment.Sato, K.Pellegrino, M.Nakagawa, T.Nakagawa, T.Vosshall, L.B.
The olfactory signal transduction mechanism in insects is clearly distinct from that in vertebrates and appears to be a unique strategy that insects have acquired to respond to the olfactory environment.doi:10.1111/j.1749-6632.2009.03935.xKazushige Touhara...
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present