Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor, which binds the activating molecule (the ligand), and the ion channel are part of the same nanomolecular protein complex. This chapter will describe the properties and functions of the nicotinic acetylcholine LG...
Activation of these channels leads to a rapid (msec) response, allowing ions to flow down their electrochemical gradients (Figure 2). Nicotinic cholinergic, GABA-A, and the 5-hydroxytryptamine3 (5HT3) receptor are examples of ligand-gated ion channel sites. Sign in to download full-size ...
Ligandgatedionchannels •Channelstructure –Heteropentamer–4-transmembranepasssubunits •Neurotransmitterdiversity•Postsynapticpotentials –Excitatory–Inhibitory •Modulation Structure •Pentameric•Chargedpore –Cation/anionselective–4-passmonomer •Cytoplasmicbasket Receptoractivation •2-5ligandsper...
...e-gated channels) 电压门控通道 配体门控通道(ligand-gated channels) 配体门控通道 机械敏感通道(mechanosensitive 机械敏 …wenku.baidu.com|基于3个网页 2. 配体门控性离子通道 ...ltage-gated channels);(2)配体门控性离子通道(ligand-gated channels);(3)机 械敏感性离子通道(mechanosensitive channels...
Classification and examples Many important ion channels are ligand-gated, and they show a great degree of homology at the genetic level. The Ligand-gated ion channels are classified into three superfamilies: The Cys-loop receptors anionic
The first topic briefly reviews the categories of ligand-gated ion channels. The basic physiological properties and general molecular structure of the ligand-gated channels are then discussed using examples from the muscle nicotinic acetylcholine receptor (AChR) and the N-methyl-D-aspartate (NMDA)-...
Anion/cation selectivity is a critical property of ion channels and underpins their physiological function. Recently, there have been numerous mutagenesis studies, which have mapped sites within the ion channel-forming segments of ligand-gated ion channels that are determinants of the ion selectivity. ...
Free Essay: Ligand-gated ion channels, such as GABAA receptors, generate a current by moving ions through the pore of the channel across the membrane. Ion...
ligand-gated ion channels基本解释 配体门控离子通道;配基门控离子通道;配体依赖性离子通道 分词解释 ion〈物〉离子 channels频道( channel的名词复数 ) 猜你喜欢 marketing channels营销渠道 channels of distribution销售渠道 commercial channels商业频道 diplomatic channels外交途径 financing channels融资渠道 gated ...
Ligand-gated chloride channels and voltage-gated chloride channels are target site of insecticides. 配体门控氯离子通道和电压门控氯离子通道都是杀虫剂的作用靶标,配体门控氯离子通道是抑制剂激发膜兴奋性的基础元件,γ-氨基丁酸(GABA)受体是一种氯离子载体复合物,是目前应用的杀虫剂的主要作用位点。2...