Ligand-gated ion channel Example : nicotinicWikipedia, From
Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that bring about a diversity of fast synaptic actions. Analysis of the Caenorhabdi... AK Jones,DB Sattelle - 《Bio...
the pathways it is involved in, known interaction partners, its subcellular location, etc. This includes information about the role of individual residues, e.g., in binding a specific ligand or as active site residues in catalysis. Another important...
VSDs of different channels contain unique ligand-binding sites and are considered as potential pharmacological targets. Modular organization of ion channels points to the possibility of NMR structural studies of isolated VSDs apart from the pore. Here, the feasibility of such studies is considered by...