Ligand-gated ion channel Example : nicotinicWikipedia, From
Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that bring about a diversity of fast synaptic actions. Analysis of the Caenorhabdi... AK Jones,DB Sattelle - 《Bio...
Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. The delta subunit was present at wild-type levels in the mutant granule cells, indicating a post-translational loss of the delta subunit. These results ... A Jones,ER ...
This includes information about the role of individual residues, e.g., in binding a specific ligand or as active site residues in catalysis. Another important angle is to identify proteins that are still uncharacterized as targets for future research. Finding information takes time, due to the ...
However, many factors can compromise the resulting data and their analysis, such as the speed of solution exchange, expression of additional ion channel populations including other ligand-gated receptors and voltage-gated channels, compounds having multiple binding sites, and current desensitization and ...