Second, improvement of computer power and simulation techniques allowed an extended exploration of the interaction of realistic macromolecules. Third, simultaneous development of a variety of techniques based on atomic force microscopy, hydrodynamic flow, biomembrane probes, optical tweezers, magnetic fields ...
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Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. The interaction of ligands with G protein-coupled receptors (GPCRs) has been traditionally studied using radiolabelled variants of receptor ligands. More r... SJ Briddon,B Kellam,SJ Hill - 《Method...
2) ligand receptor interaction 配体-受体相互作用 1. Nowadays, there are accumulating evidences of that ligand receptor interaction can be simulated with computer modeling and theoretical calculation methods. 配体-受体相互作用在许多生物过程中起重要作用,计算机分子模拟技术和理论化学计算方法在配体-受体相互...
receptor-ligand interaction 专业医学词典 受体配体相互作用 与"receptor-ligand interaction"相近的词条 ... receptor gradient receptor inhibitor receptor kinase receptor kinetics receptor-ligand receptor-ligand interaction receptor-linked enzyme receptor mapping receptor mediated control、receptor-mediated control rece...
Recent mutagenesis experiments have identified some of the functional amino acids that are essential in the interaction of nicotinic agents with the binding site of the neural nicotinic acetylcholine receptor (nAChR). Although this receptor is one of the best studied and characterized the lack of deta...
The objective of this paper is to briefly outline in a non-technical way a mathematical model for some basic interaction mechanisms of importance in cell biology and immunology. We extend the existing analysis of receptor-ligand interactions and diffusion to include general geometric shapes for the ...
•theligandbindstoitsspecificreceptoronatargetcell •thisligand-receptorinteractioninducesaconformational orshape-changeinthereceptor •producesaspecificresponse-calledthecellular response •canincludeavastarrayofcompounds –e.g.smallaminoacidderivatives,smallpeptides,proteins Cell-to-cellcommunicationby...
The rate of binding of a ligand to receptors on the cell surface can be diffusion limited. We analyze the kinetics of binding, diffusion-limited in a stationary liquid, in the presence of convective mass transport. We derive a formula that expresses the reaction kinetics in terms of the mass...
A system of quantitative analysis is proposed for evaluation of ligand-receptor interaction on models of different levels of complexity. For two discrete receptor pools, binding of radio-labelled ligands to specific receptors and the mag... BN Manukhin - 《Rossiĭskii Fiziologicheskiĭ Zhurnal Im...