Med23flox/flox;Lck-Cre mice have normal thymic populations, but MED23 null T-cells poorly populate the peripheral lymphoid tissues.Lawryn, H. KasperTomofusa, FukuyamaPaul, K. Brindle
in the thymuses of Med23flox/flox;Lck-Cre mice were essentially normal, MED23 null T-cells failed to efficiently populate the peripheral lymphoid organs... H Lawryn,Kasper,Tomofusa,... - 《Plos One》 被引量: 0发表: 2014年 Functional competence of T cells in the absence of glycosylphosp...
Perp;Lck—Cre;Cre—IoxP系统 【中图分类号】 R392.5 【文献标志码】 A ReproductionandGenotypingoftheLck-CreXPerp。 ox/“。ConditionalKnock-OutMice LENGXiao.ZHOUYah . TANGHal—ming,ZHANGXiang,L儿,Jia,YANGPei,WANGYan—tang (1.Departmentof ...
Pten flox/flox Lck-Cre mice developed thymic lymphomas, but before the onset of tumors, they showed normal thymic cellularity. To reveal a regulatory ... TJ Hagenbeek,M Naspetti,F Malergue,... - 《Journal of Experimental Medicine》
mice,forthefollow-upresearchoftheroleof PerpgeneinTcellsdevelopmentandautoimmunedisease.MethodsTheimportedPerpconditionalknock-outmiceandLck-Cremicehadreproducedandgenotypedrespectively,thenthetwostrainsofmicewerecrossed,theoff-spring micewhichgenotyping Lck-Cre×Perpflox/flox weretheheterozygousmice.ResultsLck-Cre...
Knockout (KO) mice lacking WASH expression are embryonic lethal.9, 14 To circumvent this, we recently made use of a conditional loxP-based allele, which enables inducible disruption of WASH by tamoxifen-dependent Cre recombinases (Figure 1c, right panel). Consistent with these human results, ...
The pLckCre transgenic mouse available from The Jackson Laboratory, in which the proximal promoter of Lck drives Cre expression, is a commonly used Cre driver line to recombine genes flanked by loxP sites in T cells. pLckCre drives recombination early in thymocyte development and is frequently ...