These MS systems are probably the most widespread mass spectrometers because of their relatively low price and ease of operation. Working principle. In a quadrupole mass spectrometer (4) the rf and dc potentials are applied to four rods arranged in a square array (Figure 1). Ideally, rods ...
Roche Diagnostics is working on incorporating automated LC-MS/MS into their Serum Work Area, which would allow for random access testing and potentially replace immunoassay as the first-tier testing principle for certain applications. This development has the potential to greatly ...
In principle the charge states during liquid chromatography influence the charge distribution of the analytes in the MS. The same holds in changing electrospray conditions such as voltage, application of shearing gas (ionspray), different eluent or uses of eluent modifiers etc). Charge state differen...
Cytochrome P450 enzyme systemFungicidesBaculovirusRecombinant proteinsFF-MASInhibition of fungal lanosterol-14α-demethylase (CYP51) is the working principle of ... ER Trösken,M Adamska,M Arand,... - 《Toxicology》 被引量: 130发表: 2006年 Profiling Induction of Cytochrome P450 Enzyme Activity...
An LC Mass Spectrum is defined as the spectrum generated in Liquid Chromatography-Mass Spectrometry (LC-MS) through the ionization of analyte molecules using methods like ESI or APCI, resulting in the formation of ions that are then analyzed in the mass spectrometer. ...
as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques...
Specifically, three and ten days after initiating the experiment, we performed LC–MS/MS analysis to compare the plasma metabolite profiles of mice kept under normal control conditions (groups NC3d and NC10d) with those exposed to the HTH conditions (groups HTH3d and HTH10d). As shown in ...
(LC-MS/MS) is an emerging approach based on a different, often superior, detection principle, which may improve the clinical applicability of CYFRA 21-1 in cancer diagnostics. Therefore, we developed and validated a protein precipitation, immunoaffinity (IA) LC-MS/MS assay for quantitative ...
Liquid chromatography-high resolution mass spectrometry (LC-HRMS) is a popular approach for metabolomics data acquisition and requires many data processing software tools. The FAIR Principles – Findability, Accessibility, Interoperability, and Reusability – were proposed to promote open science and reusab...
The evaluation of the method according to the principles of White Analytical Chemistry showed that the DI-SPME/LC–MS method was characterized by satisfactory analytical quality, greenness, and economical use. The use of this method met the requirements of Green Chemistry. The significant advantages ...