These MS systems are probably the most widespread mass spectrometers because of their relatively low price and ease of operation. Working principle. In a quadrupole mass spectrometer (4) the rf and dc potentials are applied to four rods arranged in a square array (Figure 1). Ideally, rods ...
Roche Diagnostics is working on incorporating automated LC-MS/MS into their Serum Work Area, which would allow for random access testing and potentially replace immunoassay as the first-tier testing principle for certain applications. This development has the potential to greatly ...
In principle the charge states during liquid chromatography influence the charge distribution of the analytes in the MS. The same holds in changing electrospray conditions such as voltage, application of shearing gas (ionspray), different eluent or uses of eluent modifiers etc). Charge state differen...
LC–MS/MS method analyzed the dissolving supernatant dissolved by 100 μL acetonitrile/water (1:1, v/v). Samples were separated using an Agilent 1290 Infinity LC Ultra Performance Liquid Chromatography System (UHPLC) HILIC column; column temperature 25 °C; flow rate 0.3 mL/min; mobile phase...
Cytochrome P450 enzyme systemFungicidesBaculovirusRecombinant proteinsFF-MASInhibition of fungal lanosterol-14α-demethylase (CYP51) is the working principle of ... ER Trösken,M Adamska,M Arand,... - 《Toxicology》 被引量: 130发表: 2006年 Profiling Induction of Cytochrome P450 Enzyme Activity...
LC–MS interface technology have allowed the detection of a larger pattern of thermolabile and polar compounds or metabolites involved in sport doping. One of the major advantages of liquid introduction in MS over other ways is that biological sample preparation can be greatly simplified. Sometimes,...
(LC-MS/MS) is an emerging approach based on a different, often superior, detection principle, which may improve the clinical applicability of CYFRA 21-1 in cancer diagnostics. Therefore, we developed and validated a protein precipitation, immunoaffinity (IA) LC-MS/MS assay for quantitative ...
Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In
The evaluation of the method according to the principles of White Analytical Chemistry showed that the DI-SPME/LC–MS method was characterized by satisfactory analytical quality, greenness, and economical use. The use of this method met the requirements of Green Chemistry. The significant advantages ...
LC-MS and immunoassay can detect protein biomarkers. Immunoassays are more commonly used but can potentially be outperformed by LC-MS. These techniques have limitations including the necessity to generate separate calibration curves for each biomarker. W