This article focuses on epidermal Langerhans cells, as opposed to mucosal Langerhans cells, although these cells share many of the same features. b Of note, follicular dendritic cells found in the cortex region of lymph nodes (B cell-rich areas) are not generally considered to belong to the ...
It is still unclear whether these cells are actually LCs, as the ontogenesis of Langerin/CD207 in zebrafish is not known. Identifier markers such as Birbeck granules have been found in zebrafish. Lugo-Villarino et al. (2010) identified cells which were morphologically similar to DC of mammals ...
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC...
One explanation is that Merkel cells may support Langerhans cells that migrate into the basal layer of the bulge and then settle into this microenvironment. These mature or immature Langerhans cells, which are inhibited from circulating from the bulge to other regions, including lymph nodes and ...
Epidermal Langerhans cells (LC) are Birbeck granule-containing bone-marrow-derived cells, which are located mainly in the suprabasal layer of the epidermis... MBM Teunissen - 《Histochemical Journal》 被引量: 153发表: 1992年 Mechanisms in Allergic Contact Dermatitis These molecules, in humans encod...
Double immunoreaction of islet for integrin α6 (a) and platelet endothelial cell adhesion molecule-1 (PECAM-1) (b) showing that in the islet only endothelia are positive for integrin α6 positive. Also shown: a bright reaction in the surrounding acinar cells. Bar, 10 μm (PDF 465 ...
a punch biopsy specimen revealed dense aggregates of large epithelioid cells with abundant cytoplasm and reniform nuclei filling the papillary dermis (figure 2). similar-appearing cells were also scattered throughout the epidermis and reticular dermis. immunohistochemical staining of these mononuclear cells...
Islets of Langerhansare composed of four cell types: β cells, which produce insulin;α cells, which produceglucagon;δ cells, which producessomatostatinand thePP cells, which producepancreatic polypeptide. In the mouse, the pancreas first appears as an evagination on the dorsalsurfaceof the primi...
Cells are color-labeled by cell states (left) and inferred pseudotime (right). Note the bifurcation of progenitor into pre-LC1 and pre-LC2, then into adjacent LC1 and LC2 subsets. (E) Wave-like dynamics of the five co-expressed gene sets across the entire differentiation trajectory. Top, ...
cells which are mostly located at the basal cell layer of the epidermis (Fig.1). Therefore, we hypothesized that Langerhans cells serve as a reservoir for MCPyV and demonstrated this phenomenon by showing the presence of MCPyV-DNA sequences in microdissected Langerhans cells from dermatopathic ...