The pDCs, when exposed to viral antigens, release high doses of Interferon 1, and upon maturing, trigger an adaptive immune response. Langerhans cells belong to the myeloid line and are found in basal and suprabasal layers of the epidermis and in oral, nasal, pulmonary, corneal, vaginal, ...
Histology Langerhans cells are present in the skin and oral mucosa. While they can be found in any layer in normal skin, they are at greatest concentration in the stratum spinosum (Young 2006 ), although their location is more variable in mucosal surfaces (Upadhyay et al. 2013 ). LCs can...
, 2005). Following 5 weeks chronic UVB exposure, within NLC mice we found that the LC compartment was largely maintained; in contrast, intraepidermal γδ T cells were nearly eliminated in both NLC and DTA, consistent with the exquisite sensitivity (Ho et al., 1991) of DETCs to UVB-...
bone marrow progenitor cells, which travel through blood to home in the epidermis and become LCs[6- 8]. Cytokines such as interleukin-4 (IL-4), tumor- necrosis factora (TNF-α), and granulocyte macroph- age colony stimulating factor (GM-CSF) are thought to drive the differentiation ...
in the epidermis and become LCs6,7,8. Cytokines such as interleukin-4 (IL-4), tumor-necrosis factora (TNF-α), and granulocyte macrophage colony stimulating factor (GM-CSF) are thought to drive the differentiation process of the progenitor cells9. The resident LCs in the epidermis are ...