Dendritic cells of the skin, including epidermal Langerhans cells, langerin+ and langerinnegative dermal dendritic cells are ideally positioned to take up pathogens that enter the body through the skin or vaccines that are administered into (intradermal) or onto (epicutaneous) the skin. The antigen ...
stimulating factor (GM-CSF), interleukin (IL)-4, and tumor necrosis factor (TNF)-伪 have been shown to induce maturation of CD34+ cells along a Langerhans cell pathway.5 The factors that induce migration of the precursor cells from the peripheral circulation into the skin are, as yet, ...
1. Langerhans cell histiocytosis that impacts skin, bone and the pituitary would be termed: High-risk Single-system Multi-system Mid-risk 2. Which of the following is NOT true about Langerhans cell histiocytosis? Is is rare It is caused by a bacteria ...
Pathological Langerhans cells exhibit proliferation in various human organs [1]. While LCH lesions can manifest in different tissues, including skin, subthalamic, liver, lung, or lymphoid tissues, the disease most commonly targets bone, with the skull being the primary site of involvement [1, 2]...
bone marrow progenitor cells, which travel through blood to home in the epidermis and become LCs[6- 8]. Cytokines such as interleukin-4 (IL-4), tumor- necrosis factora (TNF-α), and granulocyte macroph- age colony stimulating factor (GM-CSF) are thought to drive the differentiation ...
electron microscopy are rod-shaped inclusions in the cytoplasm known as Birbeck granules. LCH coalesces as an eosinophilic granuloma, owing to the influx of eosinophils, macrophages, T cells, and multinucleated cells. Immunostaining highlights the expression of CD1a, Langerin (CD207), and S100.[5...
islets of Langerhans Thesaurus Medical Encyclopedia Wikipedia Related to islets of Langerhans:insulin,pancreas,somatostatin is·lets of Lang·er·hans (ī′lĭts; läng′ər-häns′) pl.n. Irregular clusters of endocrine cells scattered throughout the tissue of the pancreas that secrete insulin...
The term LCH (also known in the past as histiocytosis X) encompasses the following rare diseases: Eosinophilic Granuloma, Hand-Schuller-Christian disease, Letterer-Siwe disease, Hashimoto-Pritzker disease, in which accumulation of pathologic Langerhans cells (LCs) leads to tissue damage. LCs usually...
The mechanism of actions induced by ionizing radiation target cells remains unclear [7, 17–21]. Suppression of inflammatory processes induced by RT and RT-sensitivity of Langerhans cells are discussed [8, 9, 22]. In general, two radiotherapy indications must be distinguished: The treatment of ...
By contrast, following allogeneic bone-marrow transplantation, cutaneous graft-versus-host disease occurs and leads to the elimination of recipient Langerhans cells and their replacement with donor-derived cells. Langerhans cells are absent in mice that lack the macrophage colony-stimulating factor (M-...