Lactie acidosis is a metabolic acidosis caused by accumulation of lactate and hydrogen ion, accompanied by elevated blood lactate concentration. That lactic acidosis which is due to inadequate tissue oxygenation, termed Type A lactic acidosis, is one of the more common causes of metabolic acidosis ...
Type A: Decreased perfusion or oxygenation Type B: B1: Underlying diseases (sometimes causing type A) B2: Medication or intoxication B3:Inborn error of metabolism Lactic acidosis is an underlying process of rigor mortis. Tissue in the muscles of the deceased resort to anaerobic metabolism in the...
Langerhans cell histiocytosis (LCH) is a rare disorder, characterised by a monoclonal proliferation of aberrant histiocytes that accumulate in and infiltrate into different organs. When the hypothalamic-pituitary axis is involved, centra... ADH Brys,S Vermeersch,R Forsyth,... - 《Netherlands Journal...
Yun S, Walker CN, Vincelette ND, Anwer F. Acute renal failure and type B lactic acidosis as first manifestation of extranodal T-cell lymphoblastic lymphoma. BMJ case reports. 2014;2014.Yun S, Walker CN, Vincelette ND, Anwer F: Acute renal failure and type B lactic acidosis as first ...
Metformin-induced lactic acidosis in the presence of acute renal failure Lactic acidosis occourred in 6 metformin-treated diabetic patients. Five of them had received 1.6 to 2.4 g metformin per day over a period of weeks or year... R Assan,C Heuclin,D Ganeval,... - 《Diabetologia》...
Therapy with metformin has been associated with type B lactic acidosis. Metformin-associated lactic acidosis (MALA) is a grave but infrequent complication of metformin use and reportedly has a mortality rate up to 50%. There has been a serious debate about the exact role of metformin in the ...
There, pyruvate can follow two pathways, conversion to (a) Acetyl Co-A via pyruvate dehydrogenase (PDH), or (b) oxaloacetate via pyruvate carboxylase. In general, lactic acidosis can occur when either too much lactate is produced, too little lactate is cleared, or both. Generation of too ...
The distinction between type A and type B lactic acidosis may be blurred in cases of sepsis and septic shock. Sepsis is associated with macrocirculatory dysfunction causing arterial hypotension, microcirculatory dysfunction and decreased oxygen and nutrient extraction by tissues [53]. However, the role...
This large cohort study quantifies the association between metformin use and hospitalization with acidosis across the range of estimated glomerular
Type A lactic acidosis is primarily associated with tissue hypoxia, whereas type B aerobic lactic acidosis is associated with drugs, toxin or systemic disorders such as liver diseases, diabetes, cancer and inborn errors of metabolism (e.g. mitochondrial genetic defects). Many known drug substances ...