Lactic acidosis is pathophysiologically classified into type A and type B. The latter is a rare but potentially life-threatening emergency, mainly described in hematological malignancies. The association between Type B lactic acidosis and malignancy is known as the Warburg effect. Patients with the ...
Cohen and Woods classified lactic acidosis into type A and type B depending on the underlying mechanism, that is, the presence or absence of tissue hypoxia [37], [38]. Whilst it is important to note that the two mechanisms of lactic acidosis can coexist and be involved in both types A ...
The case highlights the importance of considering Type B lactic acidosis (in this case secondary to a hematological malignancy) and also initiating renal replacement therapy when routine measures are ineffective.关键词: Hematological malignancy hemodialysis hyperlactatemia lactic acidosis malignancy ...
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Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive...
By far the most common cause of cliniçal lactic acidosis is the circulatory insufficiency of shock (Type A lactic acidosis). There are a large number of other conditions in which lactic acidosis appears in the absence of clinical evidence of shock (Type B). The withdrawal from general use ...
Langerhans cell histiocytosis (LCH) is a rare disorder, characterised by a monoclonal proliferation of aberrant histiocytes that accumulate in and infiltrate into different organs. When the hypothalamic-pituitary axis is involved, centra... ADH Brys,S Vermeersch,R Forsyth,... - 《Netherlands Journal...
Type B: B1: Underlying diseases (sometimes causing type A) B2: Medication or intoxication B3:Inborn error of metabolism Lactic acidosis is an underlying process of rigor mortis. Tissue in the muscles of the deceased resort to anaerobic metabolism in the absence of oxygen and significant amounts ...
Although dichloroacetate (DCA) ameliorates type B lactic acidosis, its effectiveness in type A hypoxic lactic acidosis is uncertain on both theoretical and experimental grounds. Because this drug was reported recently to successfully ameliorate lactic acidosis in patients with type A lactic acidosis, we...
Type A lactic acidosis is primarily associated with tissue hypoxia, whereas type B aerobic lactic acidosis is associated with drugs, toxin or systemic disorders such as liver diseases, diabetes, cancer and inborn errors of metabolism (e.g. mitochondrial genetic defects). Many known drug substances ...