(2011). Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions-in silico study supported by in vitro expression data. BMC Syst. Biol. 5:162. doi: 10.1186/1752-0509-5-162Genc S, Kurnaz IA, Ozilgen M (2011) Astrocyte-neuron lactate shuttle may ...
Astrocytes play a key role in the maintenance of synaptic transmission by producing L‐lactate via the astrocyte‐neuron lactate shuttle (ANLS). Astrocyte activation in the spinal cord is involved in the expression of neuropathic pain. We investigated the role of the ANLS in the spinal cord on...
This article discusses the present version of the astrocyte-neuron lactate shuttle model. The model consists of two components, the enhancement of aerobic glycolysis in astrocytes and the oxidation in neurons of lactate. Astrocytes are more affected with the combination of glycolysis and glycogenolysis...
According to the astrocyte-neurone-lactate shuttle (ANLS) hypothesis, activated neurones use lactate released by astrocytes as their energy substrate. The hypothesis, based largely on in vitro experiments, postulates that lactate is derived from the uptake by astrocytes of synaptically released ...
and providing metabolic support for neurons. The astrocyte-neuron lactate shuttle model sets forth the importance of astrocytes in providing lactate for the metabolic supply of neurons under intense activity. Lactate also plays a role as a signaling molecule and has been recently studied regarding its...
Astrocyte-neuron lactate shuttle ECAR: Extracellular acidification rate OCR: Oxygen consumption rate NMDA: N-methyl-d-aspartate LTP: Long-term potentiation DCA: Dichloroacetate BBB: Blood-brain barrier HCAR1: Hydroxycarboxylic acid receptor 1
(POMC) neurons was destroyed. Therefore, lactate, not glucose, is required to maintain POMC neuron activity39, which supports the energy balance in the whole body40. Lactate is largely a promoter of the TCA cycle. The concentration of lactate in circulation is higher than that of other energy...
B. CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain. J. Physiol. 596, 351–353 (2018). Article CAS PubMed PubMed Central Google Scholar Chatton, J. Y., Pellerin, L. & Magistretti, P...
Astrocyte–neuron lactate shuttle ATP: Adenosine triphosphate C: Cytochrome c CD147: Chaperone protein for MCT1 cLDH: Cytosolicl-lactate dehydrogenase CO2: Carbon dioxide CoA: Coenzyme A; COXIV: Cytochrome oxidase complex IV Dmax: Method for determination of lactate threshold ...
Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to... L Pellerin,G Pellegri,PG Bittar,... - 《Developmenta...