L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either related to hypersensitivity to the foreign protein or to a secondary L-glutaminase activity that causes inhibition of protein...
Two cases of hyperglycemia complicating therapy of childhood ALL with the use of L-asparaginase are described. Both patients required insulin administration. The relationship between L-aspa therapy and clinical manifestation of hyperglycemia seems to indicate that this could be the side effects of the ...
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type[J] . Weiben Yong,Wen Zheng,Jun Zhu,Yuntao Zhang,Xiaopei Wang,Yan Xie,Ningjing Lin,Bo Xu,Aiping Lu,Jiyou Li.Annals of Hematology . 2009 (7)...
L-Asparaginase delivery systems targeted to minimize its side-effects VSSL PrasadTalluri, ...AiymTleuova, inAdvances in Colloid and Interface Science, 2023 Abstract L-asparaginase (L-ASP) is one of the key enzymes used in therapeutic applications, particularly to treatAcute Lymphocytic Leukemia(ALL...
l-asparaginase (l-ASNase) is an enzyme belonging to the class of amidohydrolases that catalyzes the hydrolysis of l-asparagine into l-aspartic acid and ammonia. It has been widely investigated as a biologic agent for its antineoplastic properties in treating acute lymphoblastic leukemia. The ...
L-Asparaginase is an enzyme that depletes L-Asparagine, an important nutrient for cancer cells, resulting in cancer/tumor cell starvation.
26 October 2016 enzyme conformation rationalizesaccepted:22December2016 the Wolinella succinogenesPublished:31January2017 L-asparaginase substrate specificity Hien Anh Nguyen1,2, Donald L. Durden3 & Arnon Lavie1,2 Many side effects of current FDA-approved L-asparaginases have been related ...
Production of L-Asparaginase that is free of glutaminase and urease is a major area of research. In this paper, we report the screening and isolation of fungal species collected from the soil and mosses in the Schirmacher Hills, Dronning Maud Land, Antarctica, that produce L-Asparaginase free...
Fungal production of the anti-leukemic enzyme L-asparaginase: from screening to medium development The treatment of acute lymphoblastic leukemia is challenging due to side effects, efficacy of the available drugs, and costs. Utilization of L-asparaginase as a therapeutic agent is essential to increase...
The study of enzyme immobilization using an extracorporeal shunt system is essential to eliminate the side effects of L-asparaginase (L-Asnase; including h... Juan,Qiao,Qi,... - 《Analyst》 被引量: 26发表: 2011年 l-asparaginase: an effective agent in the treatment of acute lymphoblastic le...