Here we discuss the pharmacology, pharmacokinetics, clinical trial results and potential side effects of PEG-ASP.doi:10.1517/14712590802586058Zeidan, AmerWang, Eunice SWetzler, MeirExpert Opinion on Biological TherapyZeidan A, Wang ES, Wetzler M. Pegasparaginase: where do we stand? Expert Opin Biol...
Some PEGylated therapeutics include PEG-asparaginase (Oncaspar)29, PEG-interferon-a2a (Pegasys)30, PEG-anti vascular endothelial growth factor (Macugen)31, and PEG-uricase (Kystexxa)32. Mima et al. reported that injecting PEGylated ovalbumin in mice caused an increase in anti-PEG IgM antibodies ...
生物分析专栏 | PEG修饰药物的药代动力学和生物分析 聚乙二醇(PEG)是一种被广泛应用于蛋白质和多肽等生物聚合物进行共价修饰的高分子材料[1]。PEG化修饰(PEGylation)是将PEG共价结合在药物上,以改善药物的药代动力学、药效学和免疫学特性,从而增强...
生物分析专栏 | PEG修饰药物的药代动力学和生物分析 聚乙二醇(PEG)是一种被广泛应用于蛋白质和多肽等生物聚合物进行共价修饰的高分子材料[1]。PEG化修饰(PEGylation)是将PEG共价结合在药物上,以改善药物的药代动力学、药效学和免疫学特性,从而增强其治疗效果的一种药物技术[2]。 PEG具有无毒、无免疫原性、无抗...
聚乙二醇(PEG)是一种被广泛应用于蛋白质和多肽等生物聚合物进行共价修饰的高分子材料[1]。PEG化修饰(PEGylation)是将PEG共价结合在药物上,以改善药物的药代动力学、药效学和免疫学特性,从而增强其治疗效果的一种药物技术[2]。 PEG具有无毒、无免疫原性、无抗原性、水溶性好等优点,是当今最常用的高分子材料之一...
Effects of site-directed PEGylation on L-asparaginase thermostability Cunha, Jheniffer Rabelo Published date: 11 Aug 2021, https://doi.org/10.11606/D.9.2021.tde-05082021-101113 The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on ...
A PEG-L-asparaginase construct (Oncaspar®) was also the first PEG-prodrug to reach FDA approval in 1994, for the treatment of acute lymphoblastic leukaemia (ALL) [56,50]. Nonetheless, PEG can also be conjugated to biological response modifiers such as cytokines. PEGylated-recombinant methionyl...
聚乙二醇(PEG)是一种被广泛应用于蛋白质和多肽等生物聚合物进行共价修饰的高分子材料[1]。PEG化修饰(PEGylation)是将PEG共价结合在药物上,以改善药物的药代动力学、药效学和免疫学特性,从而增强其治疗效果的一种药物技术[2]。 PEG具有无毒、无免疫原性、无抗原性、水溶性好等优点,是当今最常用的高分子材料之一...
However, anti-PEG antibodies induced by pegylated foreign enzymes such as adenosine deaminase, L-asparaginase and uricase may possess affinities similar to antibodies induced by pathogens (10−6 −10−12 M). The apparent binding avidities to PEG-EPO of the monoclonal anti-PEG IgG and IgM ...
Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients. Cancer 2007, 110, 103–111. [CrossRef] [PubMed] 29. Garay, R.P.; El-Gewely, R.; Armstrong, J.K.; Garratty, G.; Richette, P. Antibodies against polyethylene glycol...