cells/macrophages polarization. (2) PA directly increased NLRP3 inflammasome expression and activity in hepatocytes. M1 macrophages induced by PA could further enhance its expression and activity. While M2 macrophages induced by DHA significantly down-regulated its expression and activity. (3) Lipid-ind...
美国明尼苏达大学Guisheng Song研究团队发表在Gut的研究“MicroRNA-206 promotes the recruitment of CD8 T cells by driving M1 polarisation of Kupffer cells”发现MicroRNA-206能够通过KLF4-NFKB通路促进KCs的M1型极化,同时能够通过KLF4-CCL2/CCR2轴促进CD8T细胞肝内浸润,从而抑制HCC进展。 内容简介 1. AKT/Ras信...
Effect of modulation of PPAR- gamma activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease. Sci Rep. (2017) 7:44612. doi: 10.1038/srep 44612Effect of modulation of PPAR-gamma activity on Kupffer cells M1/M2 polarization in the development of non...
M2型KCs可诱导Th2型免疫应答,促进组织修复和血管新生、对炎性刺激不敏感,并具有低吞噬杀菌作用和抗原提呈能力,可导致肝脏非典型增生细胞免疫逃逸,促进肝癌癌前病变向肝癌发展。因此,在肝癌癌前病变恶变防治中,可适当调控KCs向M1型极化,抑制M2型KCs的极化,从而调控肝癌癌前病变的进展。
人巨噬细胞M1和M2的区分,大多用CD11c和CD206;小鼠的,可参考下面这篇文献里面的指标,可以用CD206,但在分群不佳的时候,也可结合结合CD206和一些M2的功能指标: 图片来源:Haloul, M., Oliveira, E.R.A., Kader, M. et al. mTORC1-media...
www.nature.com/scientificreports OPEN received: 27 October 2016 accepted: 10 February 2017 Published: 16 March 2017 Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease Wenjing Luo*, Qinyu Xu*, Qi Wang*, ...
库普弗细胞(Kupffercells,KCs)是位于肝窦中的特殊巨噬细胞,其处于血流入肝的位置,占单核巨噬细胞细胞系总数的80%~90%。KCs的表面具有特殊的功能表型,可防御经肠道来源的病毒、细菌及其代谢产物的侵袭,KCs分泌细胞因子,避免过度的炎性免疫反应,并维持肝脏环境的体内平衡。作为肝癌微环境的特殊组成部分,KCs在肝癌癌前...
YAP水平与M1标记物(CD80和CD86)呈正相关,与M2标记物(精氨酸酶1)呈负相关。此外,观察到YAP水平与肝纤维化分期和纤维化发生基因表达呈正相关。利用免疫荧光的方法,研究人员观察到NASH患者肝脏组织中YAP表达增加,且与活化的人Kupffer细胞标记物...
关键字:Kupffer小鼠肝枯否细胞;Kupffer细胞;小鼠肝枯否细胞;Kupffer cells; 公司简介 广州弗尔博生物科技有限公司(Guangzhou Fu'erbo Biological Technology Co.,Ltd.),致力于肿瘤免疫药研发临床前CRO服务和科研转化服务的国家高新技术企业。为全国客户提供PDX肿瘤标本库、原代ATCC细胞及其它源细胞、动物实验、SCI润色等产品...