Kupffer cellsare the majorphagocytic cellof the liver. Therefore, any particulate materialthat may be injected intravascularly into an animal may be found in this cell type. Injected iron also localizes in theKupffer cellof the liver. The specific response ofKupffer cellsto foreign particulate mate...
Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated therapeutically to prevent metastasis. Here, we show that...
Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2020; https://doi.org/10.1002/hep.31658. Quintana A, Erta M, Ferrer B, Comes G, Giralt M, Hidalgo J. Astrocyte-specific deficiency of interleukin-6 and its ...
Clec4fcrystallographyC‐type lectinKupffer cell receptortrimerThe C-type lectin receptor Clec4f has been identified as a specific surface marker for Kupffer cells, although its ortholog is absent in humans and its biological function remains elusive. Here, we report the crystal structure of a ...
Kupffer cells, the resident macrophages in the liver, constitute the largest population of stationary macrophages in any organ. They constitute about 30–35% of the nonparenchymal cell volume, and reside in the hepatic sinusoids adhering to the specializ
The CoA for this product (provided upon request) verifies the cell-type specific gene expression via RT-PCR only. All test parameters provided in the CoA are conducted using abm's standardized culture system and procedures. The stated values may vary under the end-user's culture conditions. ...
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The human cells also reacted with a monoclonal antibody to CD68, a specific marker for monocytes and macrophages. Third, double-immunofluorescence confocal microscopy demonstrated co-localization of the myeloperoxidase antibody and the CD68 antibody in cells lining the hepatic sinusoid. Collectively, ...
New cell-type-specific markers to study the development of the hematopoietic system are required. Our recent study (11) has identified mitochondrial UCP2 as a specific marker of monocyte/macrophage cells developing in mouse and rat liver. The liver was the major site of UCP2 expression in the...
proposed that HAV reaches hepatocytes via KC that bind complexes of HAV and HAV-specific IgA antibodies via the Fcα receptor (van Egmond et al. 2000), and subsequently transfer the virus to hepatocytes. In contrast to HBV and HCV, HAV requires the disruption of host cell membranes to ...