The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
2009. The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1. Hepatology 49: 287-296.Dom´inguez-Soto A, Aragoneses-Fenoll L, Go´mez-Aguado F et al (2009) The pathogen receptor liver and lymph ...
in addition to T cells, engrafted in the second mouse cohort, we additionally assessed in vivo CAR T cell killing activity. Variable levels of CD19+B cells were observed
Humans possess specialized immune cells known as Kupffer cells, which are resident macrophages located within the liver sinusoids. These cells play a crucial role in immune surveillance and the removal of pathogens. Zebrafish, however, do not have Kupffer cells; instead, they harbor a different popu...
(cortical cells, podocytes, proximal tubules, mesangial cells and glomerular endothelial cells) ; intestinal products (epithelial cells and myofibroblasts from ascending, transverse, descending colon, duodenum, jejunum and ilium) and liver products (Kupffer, stellate, sinusoidal endothelial and biliary ...
Immune cell composition Humans possess specialized immune cells known as Kupffer cells, which are resident macrophages located within the liver sinusoids. These cells play a crucial role in immune surveillance and the removal of pathogens. Zebrafish, however, do not have Kupffer cells; instead, they...
(pDCs) in embolized tissue (Fig.5d). In the myeloid compartment, we observed a decrease of Kupffer cell proportions in post-PVE tissues, accompanied by an increase in other Monocyte/Macrophage populations (Fig.5d), such as those expressingIGSF21, a gene with a proinflammatory role32; and ...
Our finding that human Kupffer cells express myeloperoxidase suggests a more likely oxidant because these cells may have the capacity to convert H2O2 to HOCl. Thus, Kupffer cell myeloperoxidase may be an important source of oxidative damage during chronic liver injury. In summary, our study has ...
Box plot displays the estimated cell-type fractions in an Illumina EPIC DNAm dataset of primary hepatocytes for each cell type in the liver DNAm reference matrix: Chol, cholangiocyte; Hep, hepatocyte; Kup, Kupffer cell; Lym, lymphocyte (left). P value is from a one-tailed test for ...
a, Expression t-SNE maps of marker genes for Kupffer cell subtypes. The colour bar indicates log2 normalized expression (n = 10,372 cells). b, Major pathways upregulated in the CD1C+ antigen-presenting (n = 12 genes) and LILRB5+ metabolic/immunoregulatory (n = 35 genes) Kupffer cell ...