The KMT2A-MLLT1 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human KMT2A and MLLT1 genes located on chromosome bands 11q23.3 and 19p13.3, respectively.* Rearrangements between the two genes, the KMT2A gene – also known as HRX, MLL, MLL1, TRX1, AL...
We present the first pediatric case of BPDCN with a KMT2A (MLL)-MLLT1 rearrangement confirmed by molecular study. The karyotype demonstrated a t(11;19)(q23;p13.3), trisomy 8, and trisomy 19 in all 20 metaphase cells analyzed: 48,XX,+8,t(11;19)(q23;p13.3),+19[20]. Fluorescence ...
To model the co-operativity between KMT2C mutations and the KMT2A-MLLT1 fusion, we expressed the human KMT2A-MLLT1 fusion under the zebrafish lmo2 promoter, which drives expression in early hematopoietic progenitors. Using in situ hybridization, we found that zebrafish harboring both the kmt2c...
摘要 特异性染色体重排是急性髓系白血病(acute myeloid leukemia,AML)的特点,这种重排导致2个不相邻的基因被重新拼接到一起,形成的融合基因可能是原癌基因,可激活下游信号通路,导致细胞大量增殖,形成白血病...展开更多 作者 张春玲 蔺丽慧 王小蕊 丁静 李莉 机构地区 上海市第一人民医院检验科 出处 《检验医学...