融合基因:MLL-AF9 t(9;11)(p22;q23)易位主要发生在AML中,是AML中t(11q23)最常见的易位形式。 MLL-AF9的病人的预后较差 核型结果:46.XY,t(10;11)(p12;q23) 融合基因:MLL/AF10 MLL/AF10与AML相关,染色体上表现为t(10;11)(p12;q23)的易位,主要见于AML-M5...
其中,MLLT1-ENL,MLLT2-AFF1-AF4和MLLT3-AF9与急性髓系白血病(AML)中50%的基因易位以及急性淋巴白血病(ALL)中88%的基因易位相关。ALL和AML中MLL重排(MLL-r)与较差的预后相关。不同易位伙伴对MLL-r型AML的治疗反应和生存率差异很大,如伴有MLLT3-KMT2A融合基因的AML被归属于中等预后组。 虽然超过80%的60岁以...
最常见的两个易位分别是: 主要导致急性淋巴细胞白血病的累及AFF1 (MLLT2、AF4)的易位,和主要导致急性髓系白血病的累及MLLT3(AF9)的易位。 6.变异型 KMT2A易位:其它常导致急性髓系白血病的KMT2A易位包括MLLTI(ENL)、MLLTI0(AF10)、MLLT4(AF6)以及作为伙伴基因的ELL。除了t(11;19)(q23;p13.1)导致的MLL-...
变异型 KMT2A 易位:其它常导致急性髓系白血病的 KMT2A 易位包括MLLT1(ENL)、MLLT10(AF10)、MLLT4 (AF6) 以及作为伙伴基因的ELL。除了 t(11; 19)(q23; p13. 1) 导致的 MLL-ELL 融合基因通常只见于急性髓系白血病外 ,这些融合基因主要见于急性髓系白血病,但也可见于急性淋巴细胞白血病。部分急性髓系白血病...
In leukemias controlled by the MLL-AF4 fusion protein, we use the ultra-high resolution technique Micro-Capture-C (MCC) to show that MLL-AF4 binding promotes broad, high-density regions of enhancer-promoter interactions at a subset of key targets. These enhancers are enriched for transcription...
与KMT2A(从前称之为MLL)易位的伙伴基因有120个。易位累及AFF1(MLLT2,AF4)主要导致淋巴母细胞白血病;累及MLLT3则主要导致髓系白血病,也是最常见的。此外还有很多其它导致髓系白血病的伙伴基因如MLLT1(ENL)、MLLT10(AF10)、AFDN(MLLT4,AF6)或ELL。髓系白血病伴有这些基因易位形态学和免疫表型都表现为粒-单核或...
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the
KMT2AMLLResistancePurpose of review: Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia (MLL) gene, are found in 10% and 5% of adult and children ALL cases, respectively. The most common ...
However, for the readability of the text, we use the following gene nomenclature throughout the text: MLL (KMT2A); AF4 (AFF1); LAF4 (AFF3); AF5 (AFF4); ENL (MLLT1); AF9 (MLLT3); AF6 (MLLT4); AF17 (MLLT6); AF10 (MLLT10); and AF1Q (MLLT11). RESULTS The study cohort...
Over 79 different fusion partners of MLL1 have been identified and molecularly characterized; the most common fusion partners are AF4 (AFF1), AF9 (MLLT3), AF10 (MLLT10) and ENL (MLLT1) corresponding to t(4;11), t(9;11), t(10;11) and t(11;19) translocations...