KLRG1-了解急性免疫应答的工具 在急性感染期间,抗原特异性CD8 T细胞扩增并分化表达为KLRG1highCD127low的CD8记忆前体效应细胞(MPEC)以及表达为KLRG1lowCD127high的短寿效应细胞(SLEC)。7CD127是白细胞介素7的受体,可通过增加抗凋亡因子表达来决定细胞的寿命;因此,MPEC的CD127表达水平高于SLEC。8相应图例显示了使用针对...
the ratios of CD4+T cells, CD4+CD127+T cells, CD8+T cells, CD8+CD127+T cells, and CD8+KLRG1+T cells did not change significantly in post-NAC versus pre-NAC, reflecting the limited immune activation
Furthermore, KLRG1− CD127+ cells isolated within a week after infection exhibit a gene expression profile that is related to that of memory cells isolated after clearance of the infection (Best et al., 2013). Expression of CD127 is vital for MPCs, as this is the receptor for IL-7, ...
NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
these two proteins may interact to inhibit KLRG1+CD8+T-cell effector function, leading to immune dysfunction in CLL patients [117]. In patients with FL, CD8+T-cells lose their proliferative capacity after differentiating into KLRG1+CD127−CD8+T-cells, which have a greater capacity to produce...
these two proteins may interact to inhibit KLRG1+CD8+T-cell effector function, leading to immune dysfunction in CLL patients [117]. In patients with FL, CD8+T-cells lose their proliferative capacity after differentiating into KLRG1+CD127−CD8+T-cells, which have a greater capacity to produce...
more profound increases in circulating CD8 T cells with traits of exhaustion (CD57-KLRG1+PD-1+, TIGIT+KLRG1+, and persistent down-modulation of CD127)... SA Long,J Thorpe,KC Herold,... - 《Cellular Immunology》 被引量: 6发表: 2017年 The immunome of mobilized peripheral blood stem cell...
Combination treatment augmented the number of activated CD86(+) DCs in the draining lymph nodes and increased the percentage of KLRG1(+) CD127(-)CD8(+... E Schaedler,C Remy-Ziller,J Hortelano,... - 《Vaccine》 被引量: 6发表: 2017年 PTSD is associated with an increase in aged T cell...
However, the dramatic reduction in KLRG1hi cells caused by loss of Id2 remained in the absence of Bim, such that Id2/Bim double-deficient cells form an exclusively KLRG1lo CD127hi memory precursor population. Thus we describe a role for Id2 in both the survival and differentiation of ...
In contrast, a low expression of inhibitory receptors by the remaining HCV-specific CD8+ T cells occurred in concert with a CD127hi phenotype, an early T cell differentiation stage and presence of viral sequence variations within the corresponding epitopes...