Indeed, antigen-specific CD8+ T cells targeting persistent viruses (e.g., human immunodeficiency virus and Epstein-Barr virus) have been shown to have low CD127 and high KLRG1 expressions, while CD8+ T cells targeting resolved viral antigens (e.g., FLU) typically display high CD127 and ...
KLRG1表达与活化T淋巴细胞增殖以及活化NK细胞效应功能的减少相关。3KLRG1在先天和适应性免疫系统中的白细胞调节中发挥作用,被视为一种细胞衰老或分化标记物。例如,KLRG1可用于定义急性感染4和癌症5中的CD8 T细胞亚群,以区分短寿效应(KLRG1highCD127low)以及记忆前体(KLRG1lowCD127high)CD8 T细胞。6...
than KLRG1−CD127+CD8+T-cells. Therefore, the modulation of CD8+T-cell differentiation in FL by PI3K inhibitors may promote a more effective antitumor immune response and thus improve the clinical prognosis of lymphoma patients [121]. KLRG1 may also be a marker for monitoring antitumor response...
the ratios of CD4+T cells, CD4+CD127+T cells, CD8+T cells, CD8+CD127+T cells, and CD8+KLRG1+T cells did not change significantly in post-NAC versus pre-NAC, reflecting the limited immune activation
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these two proteins may interact to inhibit KLRG1+CD8+T-cell effector function, leading to immune dysfunction in CLL patients [117]. In patients with FL, CD8+T-cells lose their proliferative capacity after differentiating into KLRG1+CD127−CD8+T-cells, which have a greater capacity to produce...
During acute infection, antigen-specific CD8 T cells expand and differentiate CD8 memory precursor effector cells (MPECs), which express KLRG1highCD127low, and short-lived effector cells (SLECs), which express KLRG1lowCD127high.7CD127, the receptor for interleukin 7, can dictate a cell’s lon...
NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
However, the dramatic reduction in KLRG1hi cells caused by loss of Id2 remained in the absence of Bim, such that Id2/Bim double-deficient cells form an exclusively KLRG1lo CD127hi memory precursor population. Thus we describe a role for Id2 in both the survival and differentiation of ...