Hu MC, Kuro-o M, Moe OW (2012) Secreted klotho and chronic kidney disease. Adv Exp Med Biol 728:126–157Klotho and chronic kidney disease. Hu MC,Kuro-o M,Moe OW. Contributions to Nephrology . 2013Hu, MC, Kuro-o, M, Moe, OW (2012) Secreted klotho and chronic kidney disease. Adv...
现从Klotho基因和蛋白的基本特性、Klotho蛋白的生物学功能及其在血管钙化、CKD矿物质骨病和CKD患儿生长发育中的作用进行综述。关键词慢性肾脏病;Klotho蛋白;血管钙化;矿物质骨病;生长发育;儿童 慢性肾脏病 (chronic kidney disease,CKD) 是一个重大的世界性公共卫生问题,...
慢性肾脏病(chronic kidney disease,CKD)是一个重大的世界性公共卫生问题,严重危害人类生命健康。据统计,每年每百万儿童中有5~10名儿童进展至终末期肾病(end stage kidney disease,ESKD)。随着CKD进展至ESKD,可发生进行性高磷血症、高钙血症及甲状旁腺激素(parathyroid hormone,PTH)、维生素D等矿物质代谢失调和生长激...
2 Klotho与移植肾保护2.1 Klotho与肾脏衰老 肾脏是容易受衰老影响的器官之一,随着年龄增长,肾脏自我修复能力降低,老年人慢性肾病(chronic kidney disease,CKD)和终末期肾病的发生率增加[21-22]。另一方面,心脏死亡器官捐献(donation after cardiac death,DCD)扩大了标...
Chronic Kidney Diseases LIN Shu -dian,ZHAN Feng, WU Wei, et al. Department of Nephrology &Rheumatology, Hainan General Hospital, Haikou570311,China【Abstract】 Objective To study the oxidative stress in patients with chronic kidney disease ( CKD) ,and to clarify therole of soluble klotho ( s-...
本课题组前期研究发现,Klotho 的表观遗传学改变(主要是 DNA 甲基化)参与慢性肾脏病(chronickidneydisease,CKD )相关血管钙化的发生,说明其在 CKD 发生发展中发挥一定作用。本文对 Klotho 及其在 CKD 中作用的研究进展作一综述。1 犓犾狅狋犺狅 家族Klotho家族包括αKlotho、βKlotho和γ Klotho 。成纤维生长因子(...
作用,其减少klotho的释放,这在不同的研究中已经证明是有效的(lekawanvijit s,chronic kidney disease ‑ induced cardiac fibrosis is ameliorated by reducing circulating levels of a non ‑ dialysable uremic toxin,indoxylsulphate.plos one.2012)。
The incidence of chronic kidney disease (CKD) gradually increased. With the decline of renal function, CKD patients gradually appear intractable hypertension, anemia, malnutrition, calcium and phosphorus metabolic disorders, micro-inflammatory State and other complications which can seriously affect the surv...
Osteoporosis associated with chronic kidney disease - ScienceDirect Chronic kidney disease (CKD) is associated with high rates of fracture, cardiovascular events, and mortality. The pathophysiology is complex, including reduced levels of Klotho and active vitamin D, and markedly elevated levels of fibrob...
The authors use the NHANES database to study the relationship between serum klotho levels and kidney stone incidence. Multiple issues will need to be addressed to strengthen the study. 作者利用 NHANES 数据库研究了血清 klotho 水平与肾结石发病率之间的关系。要加强这项研究,需要解决多个问题。