α-Klotho (KL) was originally discovered as a soluble anti-aging factor, which is mainly expressed in kidney tubular epithelium, choroid plexus in the brain and secreted in the blood. However, the role of KL in DR pathophysiology has not been previously reported. Methods Type 1 (streptozotocin...
FGF21 is regarded as an antiaging hormone, because mice overexpressing FGF21 live longer than wild-type mice. Both FGF23 and FGF21 start increasing since early stages during the course of chronic kidney disease (CKD) progression. The increase in FGF23 compensates for decrease in the functional...
10.1038/ncomms2240 Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart Jian Xie1, Seung-Kuy Cha1,*,w, Sung-Wan An1,*, Makoto Kuro-o2, Lutz Birnbaumer3 & Chou-Long Huang1 Klotho is a membrane protein predominantly produced in the kidney that exerts some ...
The incidence and prevalence of DR increase with age; therefore, aging is considered an important risk factor for DR development [3,4]. Patients with DR experience have increased oxidative stress [5], which accelerates cellular aging through DNA damage [6]. Therefore, cellular senescence may be ...
aging society, there has been a rapid increase in the number of elderly patients with heart failure. Serum levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, are increased in patients with heart failure and show a correlation with the severity and prognosis of the ...
Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho 褪黑素通过诱导抗衰老蛋白Klotho减轻顺铂诱导的大鼠急性肾损伤 相关领域 纺神星 褪黑素 肾 蛋白激酶B 氧化应激 内分泌学 细胞凋亡 内科学 急性肾损伤 血尿素氮 化学 肌酐 半胱氨酸蛋白酶3 医学 ...
The α-Klotho mouse is an animal model that prematurely shows phenotypes resembling human aging, such as osteoporosis, arteriosclerosis, pulmonary emphysema, and kidney damage. Interestingly, these abnormalities are triggered by a deficiency of a single protein, α-Klotho. The kidney is an organ ...
Conclusion This study provides the first evidence that Klotho deficiency-induced kidney damage may be partly attributed to downregulation of GR expression. In vivo delivery of AAV-GR may be a promising therapeutic approach for aging-related kidney damage....
The α-Klotho is crucial for human health and longevity. However, the relationship between trace elements and α-Klotho levels needs further invest
Zuo Z,Lei H,Wang X,et al.Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age . 2011Zuo Z,Lei H,Wang X,et al.Aging-related kidney damage is associated with a decrease in klotho expression and an increase in ...