alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature. 2018;553(7689):461-6.G. Chen, Y. Liu, R. Goetz, et al., "alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling," Nature, vol. 553, no. 7689, pp. 461-466, 2018....
Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both displaying significant homology to members of the β-glycosidase family. Klotho is expressed in the kidney, brain, and various endocrine tissues, but can also be cleaved and act as a circulating hormone. Klotho...
Abbas, N. A. T., El Salem, A., & Awad, M. M. (2018). Empagliflozin, SGLT(2) inhibitor, attenuates renal fibrosis in rats exposed to unilateral ureteric obstruction: potential role of klotho expression. Naunyn-Schmiedeberg’s Archives of Pharmacology, 391(12), 1347–1360. CAS PubMed ...
Recently, a mutation in a third gene, KL, was found to cause a phenotype very much resembling HFTC [26], [27]. KL encodes Klotho, which functions as a co-receptor for FGF23 [28]. Although it is clear that ppGalNacT3, FGF23 or Klotho deficiency affects Pi homeostasis systemically ...
sexually inexperienced Finnish Landrace rams during the ovine nonbreeding (July) and breeding (October) seasons to determine the influence of components of the rams' mating behavior on the secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and testosterone. ...
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice Recent studies have demonstrated that klotho protein plays a role in calcium/phosphate homeostasis. The goal of the present study was to investigate the re... H Segawa,S Yamanaka,Y Ohno,... - 《Am ...
1451892_at Klotho Kl 2.597 0.014 1423581_at N-Myristoyltransferase 2 Nmt2 2.597 0.014 1420797_at Otogelin Otog 2.532 0.043 1439435_x_at Phosphoglycerate kinase 1 Pgk1 2.451 0.014 1451501_a_at Growth hormone receptor Ghr 2.439 0.014 1425582_a_at Endomucin MGI:1891716 2.336 0,014 1417978_at Eu...
Klotho (Klotho) has undeniably shown renoprotective properties; however, the molecular mechanisms through which it safeguards the glomeruli are not yet fully elucidated. Podocytes, the focus of recent studies, show Klotho expression, a factor contributing to the protection of glomeruli through mechanisms...
As a phosphaturic hormone, FGF23 is stimulated by decreased renal phos- phate excretion and subsequent hyperphosphatemia due to a declining glomerular filtration rate in patients with CKD [25]; therefore, it is reasonable that these markers related to iP homeostasis (cCa, iP, ALP, and iPTH) ...
FGF23 Regulates Bone Mineralization in a 1,25(OH)2D3 and Klotho-Independent Manner Fibroblast growth factor-23 (Fgf23) is a bone-derived hormone, suppressing phosphate reabsorption and vitamin D hormone (1,25(OH)2D3)... Sathish,Kumar,Murali,... - 《Journal of Bone & Mineral Research》 ...