presumably due to the action of protein phosphatases. On the other hand, Hsp90Y197phosphorylation was markedly more efficient in the context of a ternary complex with Cdc37 and bRaf, compared to either the free state
The study of phosphorylase kinase (PhK)-regulated glycogen metabolism has contributed to the fundamental understanding of protein phosphorylation; however, the molecular mechanism of PhK remains poorly understood. Here we present the high-resolution cryo-electron microscopy structures of human muscle PhK. ...
第二篇文章的题目是PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance,由爱丁堡大学惠康细胞生物学中心的A. Arockia Jeyaprakash教授主导,深入探讨了PLK1如何通过磷酸化Mis18复合物,促进CENP-A的精确加载,维持着丝粒的身份。 在细胞分裂的精准舞台,遗传物质的精准分配对于维持...
Ca2+mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro, which positively regulates Miro localization to, and the integrity of, ERMCS. Our results elucidate a regulatory mechanism underlying Ca2+mito homeostasis and how its dysregulation may affect NSC ...
Experiments with phospho-amino acid-specific antibodies indicate that the S phase-specific mobility shift is due to the phosphorylation at specific N-terminal (S/T)(S/T)P residues of the MCM4 protein. These specific phosphorylation events are not observed in mouse ES cells deficient in Cdc7 ...
Protein phosphorylation is a major form of post-translational modification (PTM) that regulates diverse cellular processes. In silico methods for phosphorylation site prediction can provide a useful and complementary strategy for complete phosphoproteome annotation. Here, we present a novel bioinformatics too...
Agonist-mediated receptor phosphorylation by one or more of the members of the G-protein receptor kinase (GRK) family is an established model for G-protein-coupled receptor (GPCR) phosphorylation resulting in receptor desensitization. Our recent studies have, however, suggested that an alternative rou...
Haspin kinases are mitotic kinases that are well-conserved from yeast to human. Human Haspin is a histone H3 Thr3 kinase that has important roles in chromosome cohesion during mitosis. Moreover, phosphorylation of histone H3 at Thr3 by Haspin in fission
The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR. 细胞定位 Cytosol;Endoplasmic reticulum;Nucleus;Plasma Membrane; UniProt P27986 公司简介 爱必信(上海)生物科技有限公司是一家从事生物学试剂及耗材的...
Colocalization of Stk33 with vimentin by double immunofluorescence in certain cells indicated that vimentin might be a target for phosphorylation by the novel kinase Stk33. We therefore tested in vitro the ability of Stk33 to phosphorylate recombinant fu