The invention provides novel tyrosine phosphorylation sites on the TNKl protein (see Table 1) which were identified in carcinoma and/or leukemia (e.g., human Hodgkin's lymphoma). In addition, the invention provides binding agents (e.g., antibodies) that are able to specifically bind to ...
TYROSINE PHOSPHORYLATION SITES IN TNK1 KINASE 专利名称：TYROSINE PHOSPHORYLATION SITES IN TNK1 KINASE 发明人：GU, Ting-Lei 申请号：US2009003454 申请日：20090608 公开号：WO09/148628P1 公开日：20091210 专利内容由知识产权出版社提供 摘要：The invention discloses novel phosphorylation sites in the TNKl ...
kinaseCalpha via the phosphorylation ofserine(Ser591) at C-terminal of SHP1, leading to the inhibition of SHP1 activity [20]. SHP1 dephosphorylates certain substrate signaling mechanisms, which are mediated by Src-family protein tyrosine kinases (SFKs) andspleen tyrosine kinase(SYK) [5]. A ...
Using this assay we have shown that short tyrosine-containing derived from the cytoplasmic domain of the platelet-derived beta receptor (PDGF-R) can serve as specific targets for the kinase. These include 7 out of 8 tyrosines that are known auto- or transphosphorylation sites in vivo, as ...
Stimulation of tyrosine kinase activity by oxidants has been well documented through numerous laboratory studies (Nakamura et al. 1993; Staal et al. 1994; reviewed in Suzuki et al. 1997); however, it has not yet been elucidated whether ROS cause direct phosphorylation of tyrosine kinases, or ...
Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its phosphorylation status and its multiple phosphorylation sites predict several Syk conformations. In this report, we characteriz...
In an in vitro study, phosphorylation at this site by Lck, a non-receptor-type tyrosine kinase, enhanced the basal enzymatic activity and elevated its maximal velocity in the presence of diacylglycerol. The mutation of Tyr-311 to phenylalanine prevented the increase in this maximal activity, but...
Fig. 4: Phosphorylation motifs for the human Tyr kinome enable broad categorization of phosphosites and reveal functional correspondence with the SH2-ome. a, Comprehensive scoring of the Tyr phosphoproteome by all Tyr kinase motifs.b, Annotation of the human Tyr phosphoproteome by percentile scores ...
Therefore, this is a sequence that is recognized efficiently by a tyrosine protein kinase in vivo. Phosphorylation of tyrosine in cellular proteins appears to play a role in malignant transformation by four classes of genetically distinct RNA tumor viruses. Phosphorylated tyrosines in several other ...
Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9. 来自 Semantic Scholar 喜欢 0 阅读量: 469 作者: Soans,C.摘要: Cek9 is a receptor tyrosine kinase of the Eph subfamily for which only a partial cDNA sequence was known (Sajjadi, F....