D-tyrosine is known to negatively regulate melanin synthesis by inhibiting tyrosinase activity. Here, we further reveal that peptides containing terminal D-tyrosine can reduce the melanin contents of human melanocytes. The addition of D-tyrosine to the t
Sensitivity toward tyrosine kinase inhibitors varies between different FLT3 mutations Several groups of tyrosine kinase inhibitors have been developed to inhibit kinase activity of RTK family members. AG1296, a compound from the class of tyrphostins, and the indolinone compound SU5614 both act as ade...
2C-G). The binding of FGF9 up-regulates the kinase activity of the receptor leading to dissociation of GRB2 from FGFR216 (Fig. 3A-C). These conditions closely resemble those seen in cells with depleted expression levels of the adaptor protein where the receptor also sustains DRM fractions ...
Two distinct groups of FLT3 mutations are found: internal tandem duplications (ITDs) of the juxtamembrane region and point mutations within the tyrosine kinase domain (TKD). Recently, point mutations within the activation loop of FLT3 have also been described in childhood acute lymphoblastic leukemia...
To control for donor variability, we added identical quantities of counting beads as a reference. The number of TH+ monocytes was quantified by flow cytometry (Fig. 6b, left) in two experimental groups: TPA-treated and TNFα-treated. Monocytes in each condition were gated to isolate single ce...
PTP-PEST is phosphorylated by PKC and protein kinase A at Ser39 and Ser435, and this serine phosphorylation down-regulates its activity (27). Association with other proteins (28) may also control the activity of protein-tyrosine phosphatases, and ShcA has been suggested to recruit PTP-PEST ...