Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of ...
Renal cell carcinoma (RCC) is one of the most common malignancies of the urinary tract, and its incidence continues to increase worldwide [1]. RCC is divided into three main histological subtypes: clear cell RCC or kidney renal clear cell carcinoma (ccRCC or KIRC), papillary cell RCC or ki...
Kidney cancer is one of the most prevalent malignancies, with over 400,000 new cases, and 175,000 cancer-related deaths occurring annually across the globe [1]. Kidney renal clear cell carcinoma (KIRC) the most common subtype of kidney cancers, accounting for >70% of all kidney cancers. Th...
The present study aimed to analyze RNA‑seq data of kidney renal clear cell carcinoma (KIRC) to identify prognostic genes. RNA‑seq data were downloaded from The Cancer Genome Atlas. Feature genes with a coefficient of variation (CV) >0.5 were selected using the genef...
BCL-2-associated athanogene 3 (BAG3) is an anti-apoptotic protein that plays an essential role in the onset and progression of multiple cancer types. However, the clinical significance of BAG3 in kidney renal clear cell carcinoma (KIRC) remains unclear.
Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role
Kidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. This study aims to develop new biomarkers for KIRC and explore the impact of biomarkers on the immunotherapeutic efficacy for KIRC, providing a theoretical basis for the treatment of KIRC patients. Methods...
1 Kidney renal clear cell carcinoma (KIRC) is the most common type of renal cancer, with patients often experiencing recurrence after surgery. Additionally, some patients develop resistance to adjuvant treatments, leading to poor survival outcomes.2 As a result, researchers are focusing on ...
Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs are detected incidentally during the diagnostic procedures to identify renal cell carcinoma (RCC). Thus, sensitive and accurate KIRC diagnostic methods are req...
The present study aimed to analyze RNA-seq data of kidney renal clear cell carcinoma (KIRC) to identify prognostic genes. RNA-seq data were downloaded from The Cancer Genome Atlas. Feature genes with a coefficient of variation (CV) >0.5 were selected using the genefilter package in R. Gene ...