分享一篇2022年9月发表在Frontiers in Immunology(IF:8.768)的文章《Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma》主要研究铜死亡在肾透明细胞癌(KIRC)中的机制,并结合单细胞的方法进行分析。 1.背景&方法 ...
目的探究E3泛素连接酶HECW2(HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2)在肾透明细胞癌(kidney renal clear cell carcinoma, KIRC)细胞活力、凋亡、侵袭和迁移中的作用及其分子调控机制。 方法借助GEPIA(Gene Ex...
To analyse transcriptomic data of kidney renal clear cell carcinoma(KIRC), a modified classification model is constructed using the self-attention mechanism. A new self-attention subtype recognition neural network(SSRNN)is constructed, which includes an encoder and classifier and takes ...
Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role
CELL migrationKidney renal clear cell carcinoma (KIRC) is the most prevalent type of kidney cancer and causes thousands of deaths each year. The prognosis for KIRC is poor. One critical factor is that the mechanism beneath KIRC is unclear. ORM1 is a reactant to acute inflammation. In this ...
Background: Despite the rapid advances in modern medical technology, kidney renal clear cell carcinoma (KIRC) remains a challenging clinical problem in urology. Researchers urgently search for useful markers to break through the therapeutic conundrum due to its high lethality...
Kidney renal clear cell carcinomaADME genesGene signatureSurvivalImmune cell infiltrationKidney renal clear cell carcinoma (KIRC) is the most prevalent subtype of kidney cancer. Although multiple therapeutic agents have been proven effective in KIRC, their clinical application has been hindered by a lack...
Shyr, "Transcriptome-wide signatures of tumor stage in kidney renal clear cell carcinoma: connecting copy number variation, methylation and transcrip- tion factor activity," Genome Medicine, vol. 6, no. 12, p. 117, 2014.Liu, Q., Su, P.-F., Zhao, S. & Shyr, Y. Transcriptome-wide ...
RENAL cell carcinomaTUMOR microenvironmentEPITHELIAL cell tumorsMULTIOMICSGENE expressionBackground: Kidney renal clear cell carcinoma (KIRC) is the most frequently diagnosed subtype of renal cell carcinoma (RCC); however, the pathogenesis and diagnostic approaches for KIRC remain ...
The administration of mRNA-based tumour vaccines is considered a promising strategy in tumour immunotherapy, although its application against kidney renal clear cell carcinoma (KIRC) is still at its infancy stage. The purpose of this study was to identify potential antigens and t...