Clear cell renal cell carcinoma (ccRCC) displays molecular and histologic heterogeneity. Previously described subsets of this disease, ccA and ccB, were defined based on multigene expression profiles, but it is unclear whether these subgroupings reflect the full spectrum of disease or how these ...
Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immune microenvironment of ccRCC, we applied single-cell-RNA sequencing (SCRS) along with T-c...
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. ...
Clear cell renal cell carcinoma (ccRCC) is the most common adult renal neoplasm and its incidence continues to increase. Collagen is the most abundant extracellular matrix protein in stroma, and contributes to the development and progression of ccRCC. We examined the human collagen type XXIII α1...
Renal cell carcinoma is the most common primary malignancy of the kidney. This tumor accounts for 2% of all cancer diagnoses in humans [1]. Among the RCC histologic subtypes, the vast majority are classified as clear cell renal cell carcinoma (CCRCC) [2]. Although renal tumors are usually ...
DOI:10.1016/j.cell.2017.04.016 摘要: 肿瘤微环境中的免疫细胞调节癌症进展,是有吸引力的治疗靶点。巨噬细胞和 T 细胞是微环境的关键组成部分,但它们在这个生态系统中的表型和关系以及与临床结果的关系尚不清楚。我们使用质谱流式细胞术和广泛的抗体组对来自 73 名透明细胞肾细胞癌 (ccRCC) 患者和 5 名健康对...
Clear cell renal cell carcinomaCTMRIMutational statusRadiogenomicsPurpose To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC). Materials and methods This multi-institutional, multi-reader study included 103 patients (77 men; median age 59...
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. Redox metabolism has been recognized as the hallmark of cancer. But the concrete role of redox-related genes in patient stratification of ccRCC remains unknown. Herein, we aimed to characterize the molecul...
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tumor adjacent tissues, we find that ccRCC shows exten...
Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1). We surveyed more than 400 tumours using different genomic platforms and identified 19 sig...