KI-67 indexMolecular subtypesPrognostic factorINTERNATIONAL EXPERT CONSENSUSCLINICOPATHOLOGICAL CHARACTERISTICSADJUVANT CHEMOTHERAPYHORMONE-RECEPTORPRIMARY THERAPYKI67Aim: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-...
INTRODUCTION: Breast cancer (BC) is a malignancy with very high incidence and mortality in Africa, especially in Western Africa where more than 25 thousand deaths are registered every year. Not all BC have the same prognosis, and being able to personaliz
Ki-67 APP, Breast Cancer Certified under IVDR The Ki-67 protein is associated with cellular proliferation and can be assessed by Ki-67-immunohistochemical (IHC) staining. The calculated proliferation index can be correlated to the tumor grade and the clinical course....
Background: Upfront chemotherapy is considered the standard of care in the management of early breast cancer including node-positive disease. Ki-67 proliferation index is a biomarker that can be used to predict the histo-pathological response to therapeutic upfront chemotherapy in the breast primary...
Changes in PgR and Ki-67 in residual tumour and outcome of breast cancer patients treated with neoadjuvant chemotherapy. Ann Oncol, 2015,26(2):307–313 Article CAS PubMed Google Scholar Ianza A, Giudici F, Pinello C, et al.ΔKi67 proliferation index as independent predictive and prognostic...
All included patients were needed to fulfill the following criterial: (1) pathological confirmed invasive breast cancer; (2) negative or 1–3 lymph node metastasis; (3) breast cancer among woman; (4). information about HER2 expression, HR status, and Ki-67 index could be available. This ...
The proliferation index (PI) is crucial in histopathologic diagnostics, in particular tumors. It is calculated based on Ki-67 protein expression by immunohistochemistry. PI is routinely evaluated by a visual assessment of the sample by a pathologist. How
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of th
Although Ki-67 is a commonly used measure of cellular proliferation in breast cancer tissue, its utility as a biomarker for helping to guide therapy decisions has been clouded by technical and clinical questions. However, recent efforts to develop a framework for analyzing Ki-67 and data from ...
Immunohistochemical labeling and scoring of cancer tissues Ki-67 proliferation index was assessed by immunohistochemistry (rabbit monoclonal antibody, clone 30-9, catalog number 790-4286, Ventana Medical Systems, Inc.,) on tissue microarrays (TMAs) containing 19 pairs of matched primary human invasive ...