[7]“Chen, Xianyu et al. “The predictive value of Ki-67 before neoadjuvant chemotherapy for breast cancer: a systematic review and meta-analysis.” Future oncology (London, England) vol. 13,9 (2017): 843-857. doi:...
于是利用这个特性,可以用相应的抗体给细胞染色,从而知道在某一个时间点上,究竟有多少的细胞处在分裂增殖的阶段,有多少细胞处在静止的阶段,Ki-67就成为判断肿瘤细胞活跃程度的一个非常重要的指标,Ki-67水平越高,说明处于分裂阶段的细胞...
3.水若鸿,杨文涛. 乳腺癌雌、孕激素受体免疫组织化学检测中的常用抗体. 中华病理学杂志,2015,44(4):229-231 3.NishimuraR, Osako T, Okumura Y, et al. Clinical significance of Ki-67 in neoadjuvantchemotherapy for primary breast cancer as a predictor for chemosensitivity andfor prognosis. Breast Can...
[9]Davey MG, Hynes SO, Kerin MJ, Miller N, Lowery AJ. Ki-67 as a Prognostic Biomarker in Invasive Breast Cancer. Cancers (Basel). 2021 Sep 3;13(17):4455. doi: 10.3390/cancers13174455. PMID: 34503265; PMCID: PMC8430879.
[1]Scholzen T,Gerdes J.The Ki-67 protein:from the known and the unknown.J Cell Physiol.2000;182(3):311-322。 [2]Heinzelmann-Schwarz VA,Jäger W.Ki-67 expression pattern and its relevance for endocrine resistance in breast cancer.Pathology.2019;51(2):127-128。
Abemaciclib was originally FDA approved for patients with ER-positive/HER2-negative breast cancer with Ki-67 expression >20%. However, there were no guidelines provided on which specimen to test or which scoring method to use. We performed a comprehensive study evaluating the variation in Ki-67 ...
Footnote d revised: In patients with HR-positive/HER2-negative, high-risk breast cancer (ie, those with ≥4 positive lymph nodes (confirmed preoperatively and/or at surgery), or 1-3 positive lymph nodes with one or more of the following: grade 3 disease, tumor size ≥5 cm (on pre-ope...
[1]Scholzen T,Gerdes J.The Ki-67 protein:from the known and the unknown.J Cell Physiol.2000;182(3):311-322. [2]Heinzelmann-Schwarz VA,Jäger W.Ki-67 expression pattern and its relevance for endocrine resistance in breast cancer.Pathology.2019;51(2):127-128。
. conclusions tnbc with high ki-67 was associated with a more aggressive clinical feature despite a higher pcr rate. high proliferation index ki-67 can be used for further classification of tnbc into two subtypes with different responses and prognosis. introduction triple negative breast cancer ...
four automated analysis steps. Once started, it automatically separates the sample tissue from control tissues and robustly identifies invasive cancer areas in the sample. Tumor nuclei are counted based on their Ki-67 expression and the resulting proliferation index for the whole tumor area is ...