参考文献来源: ①Ibrahim T, Farolfi A,Scarpi E,et al.Hormonal receptor,human epidermal growth factor receptor-2,and Ki67 discordance between primary breast cancer and paired. ②Nielsen TO, Leung SC, Rimm DL, et al. Assessment of Ki67 in...
Ki67, a marker of cellular proliferation, is commonly assessed in surgical pathology laboratories. In breast cancer, Ki67 is an established prognostic factor with higher levels associated with worse long-term survival. However, Ki67 IHC is considered of limited clinical use in breast cancer management...
Yerushalmi R, Woods R, Ravdin PM, et al. Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010;11(2):174-183. 曹丹霞, 何建蓉, 沈坤炜, 等. 激素受体和HER2及Ki67预测乳腺癌新辅助化疗疗效价值的分析. 中华肿瘤防治杂志. 2012;19(13):1000-1003. Montagna E, Bag...
Objectives: To evaluate Ki67 immunoexpression pattern in Saudi breast cancer (BC) patients and investigate any possible predictive or prognostic value for Ki67. Methods: This is a retrospective study designed to quantitatively assess the Ki67 proliferative index (PI) in retrieved paraffin blocks of 115...
Staining was most frequently seen in poorly differentiated tumours showing high rates of mitotic activity, but was independent of tumour size, lymph-node status and ER expression. A high level of Ki67 immunostaining was often associated with early recurrence of breast cancer after mastectomy. These ...
The expression of Ki67 in breast cancer has been associated with the luminal B phenotype, a high risk of relapse, and likelihood of good response to neoadjuvant chemotherapy. Several guidelines propose assays to determine Ki67 expression levels to select which patients with early stage breast cancer...
[1] Gerdes J, Schwab U, Lemke H, et al. Production of a mousemonoclonal antibody reactive with a human nuclear antigenassociated with cell proliferation[J]. Int J Cancer, 1983, 31(1): 13-20. [2] Nielsen TO, Leung SCY, Rimm DL, et al. Assessment of Ki67 in Breast Cancer: Updated...
[2] Nielsen TO, Leung SCY, Rimm DL, et al. Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group. J Natl Cancer Inst. 2021;113(7):808-819. doi:10.1093/jnci...
They have evaluated Ki67 in a cohort from the Tuscan Cancer Registry [1] and compared the results with the data published in our recent manuscript [2]. The main difference between both studies is the different selection of patients. GeparTrio was a chemotherapy trial with inclusion criteria ...
Ki67 Index in Breast Cancer: Correlation with Other Prognostic Markers and Potential in Pakistani Patients Ki67 index in breast cancer: correlation with other prognostic markers and potential in Pakistani patients. Asian Pac J Cancer Prev 2013; 14: 4353-4358... S Haroon,AA Hashmi,A Khurshid,.....