Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional studyKi67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we ...
Therefore, reporting of the Ki67 results should include a detailed description of how the scoring was performed. Although hotspot scores may have a better clinical utility, its reproducibility needs to be improved. Methods Subjects A total of 240 subjects with ER-positive breast cancer were analyzed...
Multivariate risk models are commonly used in clinical practice to estimate a woman's lifetime risk for breast cancer and assist in implementation of appropriate screening and risk reduction strategies. More recently, breast cancer polygenic risk scores (PRS) have been derived and integrated into ...
The nuclear proliferation biomarker Ki67 has potential prognostic, predictive, and monitoring roles in breast cancer. Unacceptable between-laboratory variability has limited its clinical value. The International Ki67 in Breast Cancer Working Group invest
The United States Food and Drug Administration recently approved a Ki-67 immunohistochemistry (IHC) assay to identify patients with early breast cancer at high disease recurrence risk. The Oncotype Dx Breast Recurrence Score® assay has been validated in hormone receptor-positive (HR+), human epide...
Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival. Clin Cancer Res. 2005;11(2 Pt 2):951s-s958. Article CAS PubMed Google Scholar Administration FDAFaD. P210026: Ki-67 IHC...
Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients Breast Canc. Res. Treat., 153 (3) (2015), pp. 477-491 Google Scholar [8] M. Klintman The prognostic value of Ki67 is dependent on estrogen receptor status...
INTRODUCTION: Breast cancer (BC) is a malignancy with very high incidence and mortality in Africa, especially in Western Africa where more than 25 thousand deaths are registered every year. Not all BC have the same prognosis, and being able to personaliz
Tumor-infiltrating T (TIL-T) cells have recently been characterized in several human cancer types by single-cell RNA sequencing (RNA-seq)23,24,25,26,27,28,29,30. However, a comprehensive atlas of tumor-infiltrating B (TIL-B) cells is still missing. B cells recognize antigens through B ...
Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) and high-grade (basal-like)