p16/Ki-67双染,检测的是包括所有HR-HPV亚型的持续感染导致的细胞周期异常(结果),p16/Ki-67双染为宫颈癌筛查策略,提供了一种更加简单、安全且性能更优的选择。 参考文献: 【1】WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition: use of...
[16]Peeters E,Wentzensen N,Bergeron C,et al.Meta-analysis of the accuracy of p16 or p16/Ki-67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal cytology[J].Ca...
8例LSIL病变进展的患者中,有6例p16/Ki-67双染阳性,2例p16/Ki-67双染阴性,p16/Ki-67双染阳性诊断LSIL病变进展率是p16/Ki-67双染阴性的3倍。22例LSIL病变持续的患者中,有12例p16/Ki-67双染阳性,10例p16/Ki-67双染阴性,p1...
The sensitivity, specificity, positive predictive value and negative predictive value of human papillomavirus (HPV) DNA, thinprep cytologic test (TCT) and P16/Ki-67 double staining detection as primary screening method for cervical cancer and precancerous lesions were evaluated, and the feasibility ...
[1]LORENZI N P C,TERMINI L,FERREIRAFILHO E S,et al. A positive HPV test with positive pl6/Ki-67 doublestaining in self-sampled vaginal material is an accuratetool to detect women at risk for cervical cancer[j]. Canc-er Cytopathol,2022,130(1) :41-54. ...
Early breast cancerDiagnostic testHR+ breast cancerKi-67Ki-67 indexRetrospective studyTreatment patternThe National Comprehensive Cancer Network recommends that patients with hormone receptor-positive early breast cancer be considered for adjuvant endocrine therapy (ET) after primary treatment like surgical ...
Association of proliferative activity with survival in non-small cell lung cancer. All possible cut-off values for proliferative activity and their impact on overall survival (OS) are depicted for the whole test cohort (A), and in the subgroups of pulmonary ADC (B) and SQCC (C). Strong ...
For many years, staging tests have not been routinely employed for low-risk early breast cancer (EBC). However, the role of Ki-67 in determining the need for staging tests in low-risk EBC remains unclear. Our study aimed to assess the number and types of staging diagnostics, additional ima...
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Using pathological results as reference, the positive predictive value, sensitivity, specificity and accuracy of P16/Ki-67 double staining, P16 INK4α single staining and HR-HPV testing for screening of high-grade squamous intraepithelial neoplasia (HSIL) and cervical cancer were compared. Results...