Understand what weak acids and bases are. Learn the definition of acids, bases, and acidity constant. Discover examples of strong and weak acids and bases. Related to this Question What is the pH of an aqueous solution composed of 0.64 M NH4+ and 0.20 M NH3? (Ka of N...
100 Most amide- and ester-based local anesthetics are weak bases, and both protonated and unprotonated forms exist in equilibrium at normal pH. While it is the unprotonated form that easily crosses the cell membrane, only the protonated form is able to block Na+ channels. Thus, local ...
A distinguishing feature of TWIK-1 (KCNK1) is its weak inward rectification, which results in significant outward currents between -60 and 0 mV.6279 These channels are activated by PKC and inhibited by intracellular acidification.79 In contrast, TASK-1 (KCNK3) and TRAAK (KCNK4) currents ...
In contrast, fetal transcription of the rat KCNE2 gene revealed a pattern very different from the expression pattern of KCNH2 with strong and even signals in all layer of atrial and ventricular myocar- dium and a very weak signal in the tongue. At late-gestation, KCNE2 expression declined ...
Fig. 2. Mouse (NM_010610, w/o splice exon plus first 27 residues from L16912), rat (NM_031828, w/o splice exons), and human (NM_002247) BK alpha subunits (Slo). (*) single, fully conserved residue; (:) conservation of strong groups, (.) conservation of weak groups, (-) no ...
KATP is a receptor-activated weak inward rectifier channel, regulated by intracellular ATP and ADP concentrations. An increase in the ratio of ATP to ADP closes the channel, and a decrease opens it, linking the metabolic state to the cellular Em.16,41-43 Function IKATP is inhibited by intrac...
All the compounds were well tolerated in a preliminary cell-based toxicological assay and, notably, two of them (BC12 and BC13) showed weak inhibition (~10–20%) of hERG channels at 10 μM. Due to the high chemical diversity of the identified molecules, no evident structure–activity ...
Using normalised tail currents, we have constructed apparent Po curves which revealed a weak voltage dependence of KCNT1 open probability (Figure 4). The average slope of the apparent Po curves (48 ± 2, n = 13) suggested a presence of a gating charge of about 0.5, however, the nature ...
Based on the entire sample of tinnitus patients and nine Caucasian control populations, however, a weak effect on the susceptibility to tinnitus cannot be entirely ruled out. Thus power simulations indicated that we should require over 12,500 patients in order to exclude a modifying role of G38S...