acids or bases in aqueous solution due to its composition of ions. When the salt contains the conjugate acid of a weak base, the solution will be acidic due to the presence of the conjugate acid. Similarly, the solution will be basic when the salt contains the conjugate ...
Fig. 2. Mouse (NM_010610, w/o splice exon plus first 27 residues from L16912), rat (NM_031828, w/o splice exons), and human (NM_002247) BK alpha subunits (Slo). (*) single, fully conserved residue; (:) conservation of strong groups, (.) conservation of weak groups, (-) no ...
All the compounds were well tolerated in a preliminary cell-based toxicological assay and, notably, two of them (BC12 and BC13) showed weak inhibition (~10–20%) of hERG channels at 10 μM. Due to the high chemical diversity of the identified molecules, no evident structure–activity ...
Using normalised tail currents, we have constructed apparent Po curves which revealed a weak voltage dependence of KCNT1 open probability (Figure 4). The average slope of the apparent Po curves (48 ± 2, n = 13) suggested a presence of a gating charge of about 0.5, however, the nature ...
Based on the entire sample of tinnitus patients and nine Caucasian control populations, however, a weak effect on the susceptibility to tinnitus cannot be entirely ruled out. Thus power simulations indicated that we should require over 12,500 patients in order to exclude a modifying role of G38S...