TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits are functional when associated as homodimers or heterodimers. TASK channels display strong basal currents with very fast activation and inactivation kinetics. TREK channels, which comprise TREK-1 (KCNK2), TREK-2 (KCNK10), and TRAAK (KCNK4), ...
Fig. 2. Mouse (NM_010610, w/o splice exon plus first 27 residues from L16912), rat (NM_031828, w/o splice exons), and human (NM_002247) BK alpha subunits (Slo). (*) single, fully conserved residue; (:) conservation of strong groups, (.) conservation of weak groups, (-) no ...
activated (BK) potassium channels are the SKCachannels' low conductance (less than 50 pS), the weak or negligible dependence of their activity on membrane voltage, and their high affinity for calcium (EC50<1 μM) (e.g., Lancaster, B., and Zucker, R. S.,J. Physiol.475:229–239, ...
When the distribution of Kcnk3 message in mouse heart was examined by in situ hybridization, a strong, specific signal was apparent throughout both ventricles with the antisense probe (Fig.2 C). A weak antisense signal was also visualized in the atria, indicating a lower level of transcript ...